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Table 2.

Wnt11-/- kidneys have reduced numbers of nephrons

GenotypeNumber of glomeruli (±s.d.)n
Wnt11+/+ 1934±148 
Wnt11+/- 1804±52 
Wnt11-/- 1237±135 
GenotypeNumber of glomeruli (±s.d.)n
Wnt11+/+ 1934±148 
Wnt11+/- 1804±52 
Wnt11-/- 1237±135 

In order to quantify kidney size, the numbers of nephron glomeruli in Wnt11+/+, Wnt11+/- and Wnt11-/- P1 kidneys were counted from 6 μm Hematoxylin and Eosin stained sections. Wnt11-/- kidneys contain∼64% (P=0.0001) the number of glomeruli compared with Wnt11+/+. Wnt11+/- kidneys are not statistically significantly different in size from genotypically wild-type kidneys.

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