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Table 1.

In utero lethality occurs in Wnt11+/-intercrosses

Genotype
Age+/+ (%)+/- (%)-/- (%)
E9.5 (n=38) 18 63 18 
E12.5 (n=361) 24 59 17 
E18.5/P1 (n=152) 32 55 13 
Genotype
Age+/+ (%)+/- (%)-/- (%)
E9.5 (n=38) 18 63 18 
E12.5 (n=361) 24 59 17 
E18.5/P1 (n=152) 32 55 13 

The frequencies of Wnt11 genotypically wild type(Wnt11+/+), heterozygous (Wnt11+/-)and mutant homozygous (Wnt11-/-) embryos at E9.5, E12.5 and combined E18.5/P1 pups are shown. Frequencies were determined by Southern blot and PCR genotyping. Wnt11-/- are first recovered in non-Mendelian ratios beginning at E12.5 (χ2 test, P<0.001). The frequencies of Wnt11-/- continue to decline by P1. Homozygous newborn Wnt11-/- animals all die within 48 hours of birth for unknown reasons.

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