The Company of Biologists

Table 2.

Genotype and morphology of embryos from matings of Tbx3^tm1Pa/+ mice

A Proportion of phenotypically abnormal embryos (abnormal/total) of each genotype at different stages of gestation from litters in which all embryos were genotyped

Genotype

Age of embryos (dpc)

+/+ (abnormal/total)

Tbx3^tm1Pa/+ (abnormal/total)

Tbx3^tm1Pa/Tbx3^tm1Pa (abnormal/total)

8.5

0/6

0/2

0/5

9.5

1/20

1/18

5/11

10.5

1/7

0/19

7/10

11.5

0/6

1/21

8/8

12.5

2/27

0/55

27/27

16.5

0/6

1/26

9/9

Total number of embryos

141

B Number of Tbx3^tm1Pa/Tbx3^tm1Pahomozygous mutant embryos in different phenotypic categories at different stages of gestation. This table includes all of the homozygous mutant embryos in A, as well as additional mutant embryos

Age of embryos (dpc)

Normal

Abnormal limbs only

Abnormal limbs and yolk sac (live)

Dead^* (degenerating)

Total

8.5

9.5

8^{^†}

10.5

11.5

17^{^‡}

12.5

13.5

3^{^§}

14.5-18.5

15^{^¶}

Embryos had morphological features indicating death had occurred one or more days previously. Limb morphology could not be assessed in most of these embryos.

^†

Two of these embryos had open brains.

^‡

Characteristic limb abnormalities could be seen in two of these embryos.

^§

Characteristic limb abnormalities could be seen in one of these embryos.

^¶

Characteristic limb abnormalities could be seen in two of these embryos

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