Genotypes of embryos from Tbx4 heterozygous intercrosses at different embryonic ages
| . | . | Age (dpc) . | . | . | . | . | . | . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele . | Genotype . | 8.0 . | 8.5 . | 9.0 . | 9.5 . | 10.5 . | 11.0 . | 11.5 . | 13.5 . | Total § . | |||||||
| Tbx4tm1Pa | +/+ | 56 | 29 | 5 | 7 | 87 | 6 | 1 | 0 | 191 | |||||||
| +/- | 127 | 45 | 13 | 20 | 176 | 8 | 5 | 5 | 399 | ||||||||
| -/- | 60 | 18 | 7 | 9 | 84* | 5‡ | 3‡ | 2‡ | 188 | ||||||||
| Tbx4tm1.1Pa | +/+ | 8 | 1 | nd | 8 | 36 | nd | 0 | nd | 53 | |||||||
| +/- | 15 | 5 | nd | 15 | 88 | nd | 3 | nd | 126 | ||||||||
| -/- | 14 | 4 | nd | 7 | 48† | nd | 3‡ | nd | 76 | ||||||||
| . | . | Age (dpc) . | . | . | . | . | . | . | . | . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele . | Genotype . | 8.0 . | 8.5 . | 9.0 . | 9.5 . | 10.5 . | 11.0 . | 11.5 . | 13.5 . | Total § . | |||||||
| Tbx4tm1Pa | +/+ | 56 | 29 | 5 | 7 | 87 | 6 | 1 | 0 | 191 | |||||||
| +/- | 127 | 45 | 13 | 20 | 176 | 8 | 5 | 5 | 399 | ||||||||
| -/- | 60 | 18 | 7 | 9 | 84* | 5‡ | 3‡ | 2‡ | 188 | ||||||||
| Tbx4tm1.1Pa | +/+ | 8 | 1 | nd | 8 | 36 | nd | 0 | nd | 53 | |||||||
| +/- | 15 | 5 | nd | 15 | 88 | nd | 3 | nd | 126 | ||||||||
| -/- | 14 | 4 | nd | 7 | 48† | nd | 3‡ | nd | 76 | ||||||||
Approximately 20% of -/- embryos dissected before 1.00 pm were dead. 53% of-/- embryos dissected after 1.00 pm were dead.
Approximately 20% of -/- embryos dissected before 1.00 pm were dead.
Embryos were dead and degenerating. Genotypes were obtained from the yolk sac or the embryonic part of the placenta.
No significant differences from Mendelian ratios of inheritance were found for Tbx4tm1Pa (X2=0.54, P>0.25) and Tbx4tm1.1Pa (X2=4.18, P>0.15). nd,note done.