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Table 2.

Non-tumorigenic cell lines: influence of wild-type TAg and ts TAg on the p53 status of the cells

TAg
Cell lines
p53 binding
p53 status
Name p53 genotype Form 34°C 39°C 34°C 39°C
OSE   WT   N/A   N/A   N/A   Active   Active  
WI38   WT   N/A   N/A   N/A   Active   Active  
IOSE 397   WT   WT   +   +   Inactive   Inactive  
IOSE 80pc   WT   WT   +   +   Inactive   Inactive  
IOSE 166a   WT   ts   +   -   Inactive   Active  
IOSE 166h   WT   ts   +   -   Inactive   Active  
OSEC2   WT   ts   +   -   Inactive   Active  
TAg
Cell lines
p53 binding
p53 status
Name p53 genotype Form 34°C 39°C 34°C 39°C
OSE   WT   N/A   N/A   N/A   Active   Active  
WI38   WT   N/A   N/A   N/A   Active   Active  
IOSE 397   WT   WT   +   +   Inactive   Inactive  
IOSE 80pc   WT   WT   +   +   Inactive   Inactive  
IOSE 166a   WT   ts   +   -   Inactive   Active  
IOSE 166h   WT   ts   +   -   Inactive   Active  
OSEC2   WT   ts   +   -   Inactive   Active  

Cell lines: OSE, normal low-passage ovarian surface epithelium; WI38, representative control line with wild-type p53; IOSE, OSE transfected with either wild-type TAg (IOSE 397 and IOSE 80pc), ts TAg (IOSE 166a, 166h), or ts TAg plus human TERT (hTERT) (OSEC2). TAg, large T antigen; N/A, not applicable (not transfected with SV40TAg); +/-, binding to and inactivating p53/not binding to p53; ts, temperature sensitive; WT, wild type.

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