... that bistable switches also play an important role during human development, and that this might help to explain why so many developmental disorders are caused by haploinsufficiency of transcriptional regulator genes. The resulting hypothesis is the centrepiece of the Future Leader Review. What is the most...

... – who doesn't want to work on an idea they were directly involved in developing? What is important is that the ideas of ECRs can be heard and opportunities like the Biology Open Future Leader Reviews are an excellent way for young researchers to show that their ideas have potential. “A lot of ECRs...

... and evolved. For example, 50 years ago, extracellular vesicles were considered as mere ‘platelet dust’, and currently have inspired the development of a multitude of therapeutic strategies, not only for cardiovascular diseases. This represents a major opportunity for future research aiming to narrow the gaps...

... ABSTRACT Future Leader to Watch is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Olayemi Joseph Olajide is first author on ‘ Molecular mechanisms of neurodegeneration...

... ABSTRACT Future Leader to Watch is a series of interviews with the first authors of a selection of Reviews published in Biology Open, helping early-career researchers promote themselves alongside their papers. Fabrizio Alberti is first author on ‘ Recent developments of tools for genome...

... ABSTRACT Future Leaders to Watch is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Christopher Toepfer and Manuel Schmid are co-first authors on ‘ Myosin super relaxation...

... ABSTRACT Future Leaders to Watch is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Andrea Paterlini is author of ‘ Uncharted routes: exploring the relevance of auxin...

... of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author. * Author for correspondence ( tania.m.marques@fmed.uc.pt ) Competing interests The author declares no competing or financial...

... by the behaviour of the individual. Our review details how motion is intricately linked to signalling and suggests some avenues for future research. This Review has an associated Future Leader to Watch interview with the first author. Finally, movement can reduce detection as a result of the flicker-fusion...

... and topological organisation of the genome should be used to generate better hypotheses. The article has an associated Future Leader to Watch interview. © 2022. Published by The Company of Biologists Ltd 2022 This is an Open Access article distributed under the terms of the Creative Commons Attribution...

... a mechanistic, systems-level explanation of HI of transcriptional regulators, thus unifying existing theories, and offers new insights into outstanding issues of human disease. This article has an associated Future Leader to Watch interview with the author of the paper. * Author for correspondence...

... and its regulation throughout the body. This article has an associated Future Leader to Watch interview with the first author of the paper. CDC42 is directly activated by the Gα subunit coupled to 5-HT 7 ( Kvachnina et al., 2005 ). CDC42 activation is required for macropinocytosis ( Koivusalo et al...

.... Moreover, the immortal nature of germ cells suggests that immortality is retained during GLCM specification; here we suggest that the demonstrated pluripotency of GLCM accounts for retention of immortality in somatic stem cell types as well. This article has an associated Future Leaders to Watch interview...

... the governance of muscle function in human health and disease. With this review, we provide a broad overview of contemporary understanding of myosin SRX, and explore the complexities of targeting this myosin state in human disease. This article has an associated Future Leaders to Watch interview with the authors...

... has an associated Future Leader to Watch interview with the first author of the article. * Authors for correspondence ( olajide.oj@unilorin.edu.ng or joseph.olajide@concordia.ca ; andrew.chapman@concordia.ca ) Competing interests The authors declare no competing or financial interests...

... an associated Future Leader to Watch interview with the first author of the paper. * Author for correspondence ( f.alberti@warwick.ac.uk ) Competing interests The authors declare no competing or financial interests. © 2020. Published by The Company of Biologists Ltd 2020 This is an Open...

... an associated Future Leader to Watch interview with the author of the paper. * Author for correspondence ( andrea.paterlini@slcu.cam.ac.uk ) Competing interests The authors declare no competing or financial interests. © 2020. Published by The Company of Biologists Ltd 2020 This is an Open...