... organism, while offering some in vitro experimental characteristics and a higher throughput alternative to the mouse and a more realistic alternative than cell-based microphysiological systems such as organoids, organ on chip and 2D cell culture. While the techniques used in the current study have...

... Sciences http://dx.doi.org/10.13039/100000057 GM132006 University of Maine http://dx.doi.org/10.13039/100011130 The sensory epithelium of the cochlea, the organ of Corti, has a highly specialized organization containing one row of sound-detecting inner hair cells (IHCs) and three...

... and epithelial tube morphogenesis are amongst the top 10 most significant terms. GO term analysis of NPC profiles comparing low and no CHIR highlighted cytoskeletal organization and attenuated cell movement (elevated in no CHIR; Table S1.5) and cell proliferation (elevated in low CHIR; Table S1.6...

... ; Wagar et al., 2021 )] and engineering methods ( Kim et al., 2019 ) [e.g. scaffolds ( Asnaghi et al., 2021 ; Bourgine et al., 2018 ; Campinoti et al., 2020 ; Fan et al., 2015 ; Hun et al., 2016 ; Poznansky et al., 2000 ; Purwada and Singh, 2017 ) and organ-on-a-chip ( Goyal et al., 2022 )], bona...

... , L. , Lowen , J. M. et al. ( 2022 ). Organ-on-a-chip model of vascularized human bone marrow niches . Biomaterials 280 , 121245 . 10.1016/j.biomaterials.2021.121245 Görgens , A. , Ludwig , A.-K. , Möllmann , M. , Krawczyk , A. , Dürig , J. , Hanenberg...

... regulation: they are protected from the autoimmune attack by the basal ES structure, the tight junction and gap junction-based adhesion between two opposing Sertoli cells (Cheng et al., 2011b). This structure makes testes an immuno-tolerant organ and functions as barriers from auto-antigen and exogenous...

... PWMs such as forkhead genes (FOXD, FOXI, FOXA, etc.) or SRY genes (e.g. SOXC), which complicates identification of TFs binding to a particular locus in a CRM and could also lead to incorrect identification of the homolog affecting a particular gene in other organisms such as vertebrates, as discussed...

... the ability of LaA to restore nuclear deformability and to recruit emerin to the nuclear membrane in Lmna –/– MEFs. Our finding that tags impede some LaA functions but not others might explain the partial loss of function phenotypes when tagged lamins are expressed in model organisms and should caution...

... and nuclear envelope function, and, because of their large nuclear size and resistance to apoptotic signals, polyploid cells constitute a convenient system for analyzing the inter-relationships between gene expression and nuclear chromatin organization. Furthermore, the cells of the PG produce ecdysone...

... of postsynaptic differentiation. Animals lacking unc-30 or madd-4B , the short isoform of the motor neuron-secreted synapse organizer madd-4 (punctin /ADAMTSL ), display severe GABA receptor type A (GABA A R) clustering defects in postsynaptic muscle cells. Mechanistically, UNC-30 acts directly to induce...

... and Huttner, 2021 ; Libé-Philippot and Vanderhaeghen, 2021 ; Pollen et al., 2023 ; Vanderhaeghen and Polleux, 2023 ). In addition, following the availability of genomes from extinct species most closely related to us, the elucidation of the molecular underpinnings of unique aspects of brain organization...

... to ionising radiation. (B) Schematic to highlight the tissues and organs expected to be irradiated using this experimental setup. PG, parotid gland; SLG, sublingual gland; SMG, submandibular gland. (C) Experimental timeline showing the timing of fractionated (three 5 Gy doses over 5 days, 3×5 Gy) and single...

... recruitment to the angiogenic front promoted pericyte-to-VSMC transition, which was organized by tip endothelial FOXO1. © 2024. Published by The Company of Biologists Ltd. Development Accepted manuscript Abstract The microvascular system consists of two cell types: endothelial and mural (pericytes...

... of the animal jumping to a new position, while the orientation and jump distance are unaffected. These findings yield insights into how internal states in a simple organism, Hydra , affect specific elements of a behavior, and offer general principles for studying the relationship between state-dependent...

... studies have reported that non-essential kinetochore proteins contribute to kinetochore organization and thereby promote high-fidelity chromosome segregation (reviewed in Mehta et al., 2022 ). Therefore, we wished to examine kinetochore organization in the absence of Bmh proteins using a chromatin spread...

... between proliferation and differentiation in an adult stem cell lineage. The phenotype of germ cell loss followed by over-proliferation when inhibiting a histone methyltransferase also raises concerns about using their inhibitors in cancer therapy. In multicellular organisms, homeostasis...

...Orel Benita; Nir Nesher; Tal Shomrat ABSTRACT Planarians are well-known model organisms for regeneration and developmental biology research due to their remarkable regenerative capacity. Here, we aim to advocate for the use of planaria as a valuable model for neurobiology, as well. Planarians have...

... deletions in the DMD gene that result in the production of a truncated, yet functional, dystrophin protein. The consequences of BMD-causing in-frame deletions on the organism are difficult to predict, especially in regard to long-term prognosis. Here, we employed CRISPR-Cas9 to generate a new Dmd del52-55...

... promoter elements. Here, we highlight the complexity of transcriptional regulation by outlining the effect of core promoter-dependent regulation on embryonic development and the proper function of an organism. We demonstrate in vivo the importance of the downstream core promoter element (DPE) in complex...

... receptors in the functional organization of primate retinal ganglion cells . Vis. Neurosci. 11 , 317 - 332 . 10.1017/S0952523800001668 Crook , J. D. , Packer , O. S. and Dacey , D. M. ( 2014 ). A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate...