... and are responsive to tick feeding activity with the former being upregulated and the latter being downregulated. We show that they regulate tick physiological functions that may be related to A. americanum tick feeding success as revealed by RNAi-mediated dual silencing of Aam IGFBP-rP6S and Aam IGFBP-rP6L or Aam...

... strongly indicate that changing physiological needs during the tick feeding process influences transcriptional regulation of Aam Oatp. Our data also show that RNAi-mediated suppression of the Aam Oatp caused ticks to obtain smaller blood meals, which consequently resulted in ticks laying fewer eggs...