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Keywords: ryanodine
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Journal Articles
J Exp Biol (2006) 209 (10): 1956–1963.
Published: 15 May 2006
..., Python regius , the tegu lizard, Tupinanvis merianae , and the varanid lizard, Varanus exanthematicus . Force-frequency trials and imposed pauses were performed on ventricular and atrial tissue from each species with and without the SR inhibitor ryanodine, and in the absence and presence of adrenaline...
Journal Articles
J Exp Biol (2005) 208 (6): 1045–1052.
Published: 15 March 2005
... ) receptor (IP 3 R) and subsequent release of Ca 2+ from the sarcoplasmic reticulum (SR). IP 3 R-mediated release of SR Ca 2+ causes calcium-induced calcium release (CICR) via the ryanodine receptor (RyR), which can be sensitized by cyclic adeninediphosphate ribose (cADPR). cADPR is synthesized from NAD...
Journal Articles
J Exp Biol (2004) 207 (19): 3411–3417.
Published: 01 September 2004
... of the inositol trisphosphate (IP 3 ) receptors(IP 3 R), we utilized two inhibitors of the mammalian IP 3 R, TMB-8 and 2-APB. In Ca 2+ -free Ringer, these agents inhibit the response to ET B R agonist stimulation by 71%. The ryanodine-sensitive receptor (RyR) may be activated by low concentrations of ryanodine...
Journal Articles
J Exp Biol (2002) 205 (13): 1889–1897.
Published: 01 July 2002
..., increased [Ca 2+ ] i . To assess the participation of inositol triphosphate (IP 3 ) generation, sarcoplasmic/endoplasmic reticulum (SR/ER) Ca 2+ depletion, and activation of store-operated Ca 2+ entry, we utilized thapsigargin and ryanodine to deplete Ca 2+ SR/ER stores and the inhibitory reagents TMB-8...
Journal Articles
J Exp Biol (1988) 140 (1): 227–241.
Published: 01 November 1988
... were also treated with ryanodine to assess the importance of calcium release from the sarcoplasmic reticulum. Ventricle strips from skate and black dogfish showed a five-fold increase in force development when external calcium was raised from a physiological to a saturating level. Force development...