... influenced by temperature. The thermally induced changes to the regulation of specific steps within the OXPHOS process are poorly understood. In our study, we used the eurythermal species of planarian Dugesia tigrina to study the thermal sensitivity of the OXPHOS process at 10, 15, 20, 25 and 30°C. We...

... and expression were studied in the lobster Panulirus argus . Trypsin secretion was shown to be maximal 4 h after ingestion. At this time, fish- and squid-based diets induced trypsin secretion, as well as up-regulation of the major trypsin isoform at the transcription level. While fish- and squid-based diets...

...Stephen M. Secor SUMMARY As an apparent adaptation to predictably long episodes of fasting, the sit-and-wait foraging Burmese python experiences unprecedented regulation of gastrointestinal and cardiovascular performance with feeding and fasting. The ingestion of a meal signals the quiescent gut...

... is transcribed, apparently in a developmentally regulated manner, suggesting that these genomes largely encode RNA machines and that there may be a vast hidden layer of RNA regulatory transactions in the background. I propose that the epigenetic trajectories of differentiation and development are primarily...

... and cAMP-independent motility activation of demembranated sperm. This suggests that the increase in [pH] i regulates flagellar motility via cAMP-independent phosphorylation of axonemal proteins. * Author for correspondence (e-mail: [email protected] ) 28 9 2005 © The Company...

..., and a recovery only limited by the physical stability of the utilized optical system. Intracellular pH (pH i ) in Danio rerio embryos between 1k-cells stage and the end of epiboly was found to be well regulated to a mean value of 7.55±0.13 (± s . d .), a range distinctly more alkaline than typical values...

... (e-mail: [email protected] ) 12 10 2004 © The Company of Biologists Limited 2004 2004 carbohydrate exercise glycogen glycogen synthase muscle recovery regulation rat Muscle glycogen has been shown nearly four decades ago to play an important role...

... ago, wide-ranging work by many investigators has added importantly to our understanding of its function and regulation. Functionally, myoglobin is well accepted as an O 2 -storage protein in muscle, capable of releasing O 2 during periods of hypoxia or anoxia. Myoglobin is also thought to buffer...

.... Studies of metabolism have traditionally been conducted within what can considered as the kinetic paradigm provided by `solution biochemistry'; i.e. the rates of enzymatic reactions are studied in terms of their regulation by mass-action and allosteric effectors and, most recently, metabolic control...

... sesquiterpenoids that control metamorphosis in immature insects and reproduction in most adult insects. The corpora allata (CA), a pair of endocrine glands with nervous connections to the brain, synthesize and release JH. The regulation of JH synthesis is achieved by a complex interplay of stimulatory...

... ) 14 3 2003 © The Company of Biologists Limited 2003 2003 vacuolar ATPase V-ATPase portasome bafilomycin Na + /K + -ATPase serotonin 5-hydroxytryptamine regulation assembly immunocytochemistry insect blowfly Calliphora vicina . The salivary glands of the blowfly...

... catalase, superoxide dismutase and glutathione. In this review, we focus on a third role of O 2 , as a regulator of membrane transport systems, a role with important consequences for the homeostasis of the red cell and also the organism as a whole. We show that regulation of red cell transporters by O 2...

... at the catalytic site of the V-ATPase plays an important role in regulating V-ATPase activity in vivo . Other regulatory mechanisms that are discussed include reversible dissociation and reassembly of the V-ATPase complex, changes in the tightness of coupling between proton transport and ATP hydrolysis...

... between the V 1 and V o sectors is essential for ATP-driven proton transport, and this interaction is manipulated in vivo as a means of regulating V-ATPase activity. When yeast ( Saccharomyces cerevisiae ) cells are deprived of glucose for as little as 5 min, up to 75 % of the assembled V-ATPase complexes...

...Christer Hogstrand; Nathan Webb; Chris M. Wood ABSTRACT The possible coupling between regulation of the affinities for branchial Zn and Ca influx was investigated in juvenile rainbow trout Oncorhynchus mykiss acclimated to relatively hard fresh water ([Ca]=1.0 mmol l −1 ). The K m for branchial Ca...

...Martin D. Brand ABSTRACT This paper reviews top-down regulation analysis, a part of metabolic control analysis, and shows how it can be used to analyse steady states, regulation and homeostasis in complex systems such as energy metabolism in mitochondria, cells and tissues. A steady state...

... ‘homeostatic’; it is common to observe no change in ATP concentration even while the change in its turnover rate can increase or decrease by two orders of magnitude. A large number of other intermediates of cellular metabolism are also regulated within narrow concentration ranges, but none seemingly...

... composed of two structural domains, a peripheral, catalytic V 1 domain and a membrane-spanning V o domain. Both the multitude of locations and the heteromultimeric structure make it likely that the expression and the activity of V-ATPases are regulated in various ways. Regulation of gene expression...

... be deleted without altering the kinetics of the transport reaction; the regulatory properties of the antiporter are markedly affected by this deletion however. Two different modes of regulation of antiport activity have been characterized and appear to involve two different inactive states of the carrier...

...) P 3 receptors are the targets for a number of allosteric regulators, including protein kinases, ATP and divalent cations. Understanding how cells control the Ca 2+ -mobilizing activity of Ins(1,4,5) P 3 will be important if we are to unravel the mechanisms that underlie the complex arrangements...