... and by ‘deorphanisation’ of neuropeptide receptors. The evolutionary origins of at least 30 neuropeptide signalling systems have been traced to the common ancestor of protostomes and deuterostomes. Furthermore, two rounds of genome duplication gave rise to an expanded repertoire of neuropeptide signalling systems...

... affinity to the receptor that is comparable (7.6-fold less) to that of non-labeled speract. Indeed, 10 nmol l −1 eCFP-speract induces physiological sperm responses such as membrane potential changes and increases in intracellular pH and Ca 2+ concentrations similar to those triggered by 10 nmol l −1...

... receptor(s), whereas 17β-estradiol 3-glucuronate is detected via (a) distinct olfactory receptor(s). In conclusion, the Mozambique tilapia has evolved high olfactory sensitivity and specificity to 3-glucuronidated steroids through two distinct olfactory receptor types; one detecting a male sex pheromone...

... be receptors involved in binding water-borne chemicals and coupling to an intracellular signal pathway. In support of this, we found expression of a phospholipase C and an inositol trisphosphate receptor in the rhinophore sensory epithelia and possibly distributed within outer dendrites of olfactory sensory...

...Cécile Faucher; Manfred Forstreuter; Monika Hilker; Marien de Bruyne SUMMARY Drosophila melanogaster (Meigen) detects and uses many volatiles for its survival. Carbon dioxide (CO 2 ) is detected in adults by a special class of olfactory receptor neurons, expressing the gustatory receptor Gr21a...

... Manduca and the cricket Acheta ,functional studies have shown that its cognate receptor (DH-R) is related to the mammalian CRF receptor. The Drosophila genome contains two genes( CG8422 and CG1237 0) orthologous to Manduca and Acheta DH-Rs. Here, we present multiple lines of evidence to support...

... of changes of individual receptor cells' responses in the sensilla. Feeding on solanaceous foliage therefore appears to result in a modification of the physiological responses of individual taste receptor cells that causes them to be tuned to the host-recognition cue indioside D. We propose that this tuning...

... of dung and rolls it off at high speed to escape competition at and around the dung pile. Using behavioural experiments in the field and in the laboratory, we show that the beetle is able to roll along a straight path by using the polarised light pattern of evening skylight. The receptors used to detect...

... the glycoprotein hormone receptor DLGR2. Although rickets mutants produce and release the insect-tanning hormone bursicon, they do not melanize when injected with extracts containing bursicon. In contrast, mutants do melanize in response to injection of an analog of cyclic AMP, the second messenger for bursicon...

...CARRIE A. PAQUETTE; VILLA RAKOCHY; ALISON BUSH; JUDITH L. VAN HOUTEN SUMMARY We have begun to characterize the glycophosphatidylinositol (GPI)-anchored proteins of the Paramecium tetraurelia cell body surface where receptors and binding sites for attractant stimuli are found. We demonstrate here (i...

... : A brief review and a new interpretation . Biol. Bull. 188 , 120 – 127 . 10.2307/1542077 Devlin , C. L. ( 2001 ). The pharmacology of γ-aminobutyric acid and acetylcholine receptors at the echinoderm neuromuscular junction . J. Exp. Biol . 204 , 887 – 896 . 10.1242/jeb.204.5.887...

... the role of insulin and insulin-like growth factor I (IGF-I) in fish adipose tissue function, we have investigated the presence and the regulation of insulin and IGF-I receptors in adipose tissue of brown trout ( Salmo trutta ). Receptors for insulin and IGF-I were detected in trout adipose tissue...

.... In order to determine if receptors for ET are expressed in fish gill tissue, we examined the binding kinetics of 125 I-labeled, human ET-1 to membrane fragments isolated from the gill of the dogfish shark, Squalus acanthias . 125 I-ET-1 bound at a single site, with a dissociation constant ( K d...

... aortic blood flow (cardiac output, Q̇ ) were made using standard cannulation techniques and a single-crystal Doppler flowmeter. On line measurements of arterial were made using an oxygen electrode connected to an extracorporeal loop. Adenosine (10 nmol kg −1 ) and the specific A 1 -receptor agonist N 6...

...T. G. Pottinger; I. Brierley ABSTRACT Binding sites for the steroid hormone cortisol, with characteristics typical of a steroid receptor, were detected in the rainbow trout ( Oncorhynchus mykiss ) erythrocyte. Binding of [3H]cortisol to a washed and purified erythrocyte suspension was saturable ( B...

... organ systems and endocrine glands. A recently cloned G-protein-coupled receptor responds to extracellular calcium concentration (Ca 2+ o-sensing receptor, CaSR) and mediates several of the known effects of Ca 2+ o on parathyroid and renal function. The CaSR, which is also expressed in a number of other...

..., fertilization, smooth muscle contraction and secretion. Ins(1,4,5) P 3 is produced at the plasma membrane following receptor activation, but rapidly diffuses into the cytosol, where it binds to specific receptors through which it mobilizes intracellular Ca 2+ stores. The actions of Ins(1,4,5) P 3 within cells...

...-bungarotoxin. The extrasynaptic nicotinic and muscarinic receptors of Locusta migratoria neurones are pharmacologically distinct from the corresponding mammalian receptors studied so far. REFERENCES Aguilar , J. S. and Lunt , G. G. ( 1984 ). Cholinergic binding sites with muscarinic...

... was between 10 −8 and 10 −7 mol l −1 , while maximal effects were seen at approximately 10 −5 mol l −1 . The octopamine receptors were classified as octopamine2 receptors on the basis of the differential responsiveness of the muscle to the octopamine agonists naphazoline, tolazoline, clonidine...

... somewhere in this pathway. Retrograde transport and the initial signal transduction step begin when NGF binds to NGF receptors on the nerve terminal. Receptor-mediated internalization and the survival and maintenance function of NGF are mediated by the higher affinity receptors. These receptors have...