...Catherine Gaitanaki; Michalis Mastri; Ioanna-Katerina S. Aggeli; Isidoros Beis SUMMARY In the present study the activation of p38 mitogen-activated protein kinase(p38-MAPK) and c-Jun N-terminal kinases (JNKs) by hyperthermia was investigated in the isolated perfused Rana ridibunda heart...

...Catherine Gaitanaki; Theodora Kalpachidou; Ioanna-Katerina S. Aggeli; Panagiota Papazafiri; Isidoros Beis SUMMARY Mitogen-activated protein kinases (MAPKs) constitute one of the most important intracellular signalling pathways. In particular, the p38-MAPK subfamily is known to be activated under...

...Catherine Gaitanaki; Maria Pliatska; Konstantina Stathopoulou; Isidoros Beis SUMMARY In the present study, we investigated the induction of the p38-MAPK signalling pathway by copper, as exemplified by CuCl 2 , in the isolated perfused heart of the amphibian Rana ridibunda . We found that p38-MAPK...

...Konstantina Stathopoulou; Catherine Gaitanaki; Isidoros Beis SUMMARY We investigated the activation of the p38-MAPK signalling pathway during extracellular pH changes in the isolated perfused amphibian heart. Extracellular alkalosis (pH 8.5 or 9.5) maximally activated p38-MAPK within 2 min (4.17...

...Catherine Gaitanaki; Stathopoulou Konstantina; Stavridou Chrysa; Isidoros Beis SUMMARY We investigated the activation of three subfamilies of MAPKs (ERK, JNKs and p38-MAPK) by oxidative stress in the isolated perfused amphibian heart. Activation of p43-ERK by 100 μmol l -1 H 2 O 2 was maximally...

...Ioanna-Katerina S. Aggeli; Catherine Gaitanaki; Antigone Lazou; Isidoros Beis SUMMARY We investigated the activation of p38-MAPK by various adrenergic agents in the perfused Rana ridibunda heart. Phenylephrine (50 μmol l -1 ) rapidly induced the differential activation of all three mitogen...

...Ioanna-Katerina S. Aggeli; Catherine Gaitanaki; Antigone Lazou; Isidoros Beis SUMMARY We assessed the activation of p38-MAPK (mitogen-activated protein kinase) by osmotic and thermal stresses in the isolated perfused amphibian ( Rana ridibunda ) heart. Hyperosmotic stress induced the rapid...

...-activated p38-mitogen-activated protein kinase (p38-MAPK) cascade as measured by the phosphorylation of the activator of transcription factor-2 (ATF 2 ) in an immunocomplex kinase assay. Activation of the p38-MAPK cascade by a short stimulation (10 min) with the NO donor MAHMA-NO causes a large increase...