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Keywords: oxygen sensing
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Journal Articles
Journal Articles
J Exp Biol (2008) 211 (15): 2371–2378.
Published: 1 August 2008
... lamellae and pseudobranch, and discuss the physiological significance of this innervation within the context of homeostatic functions of the gill, such as oxygen sensing and ion regulation. Studies in zebrafish utilizing techniques of confocal microscopy and immunolabelling, with specific antibodies...
Journal Articles
J Exp Biol (2008) 211 (14): 2205–2213.
Published: 15 July 2008
... 2 S was enhanced at low P O 2 , it is unlikely that H 2 S contractions are mediated by either H 2 S–NO interaction or an oxidation product of H 2 S. These experiments also provide additional support for the hypothesis that the metabolism of H 2 S is involved in oxygen sensing/signal transduction...
Journal Articles
J Exp Biol (2004) 207 (18): 3171–3188.
Published: 15 August 2004
..., neoplasia and neurodegenerative disease. Complex cellular oxygen sensing systems have evolved for tight regulation of oxygen homeostasis in the brain. In response to variations in oxygen partial pressure ( P O 2 ) these induce adaptive mechanisms to avoid or at least minimize brain damage. A significant...
Journal Articles
J Exp Biol (2000) 203 (7): 1123–1130.
Published: 1 April 2000
... to the value reflective of anoxia (pH 6.7) showed that acidification alone explained over half the transcriptional arrest. Initiation of transcription was not rescued by application of 80 % carbon monoxide under anoxia, which suggests that heme-based oxygen sensing is not involved in this global arrest. When...
Journal Articles
J Exp Biol (1998) 201 (8): 1197–1201.
Published: 1 April 1998
... by which cells and tissues sense hypoxia and respond with biologically appropriate alterations in gene expression. It is likely that oxygen sensing involves a heme protein in which cobalt and nickel can substitute for iron in the porphyrin ring. Indirect evidence suggests that the sensor is present in all...
Journal Articles
J Exp Biol (1998) 201 (8): 1177–1195.
Published: 1 April 1998
..., are thought to provide a gauge of oxygen availability and dictate which set of genes will be transcribed. But the precise role of heme in oxygen sensing and the transcriptional regulation of oxygen-responsive genes is presently unclear. Here, we provide an overview of the transcriptional regulation of oxygen...