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Keywords: obesity
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Journal Articles
J Exp Biol (2022) 225 (9): jeb244178.
Published: 9 May 2022
... but does elicit temperature-specific effects on skeletal muscle contractile function. Obesity Work loop Isometric Force Power Obesity is a global epidemic (WHO, 2000), associated with poor health, reduced quality of life and increased mortality ( Abdelaal et al., 2017 ; Vásquez et al...
Journal Articles
J Exp Biol (2021) 224 (2): jeb219543.
Published: 26 January 2021
...Daniella E. Chusyd; Tim R. Nagy; Lilian Golzarri-Arroyo; Stephanie L. Dickinson; John R. Speakman; Catherine Hambly; Maria S. Johnson; David B. Allison; Janine L. Brown ABSTRACT Many captive Asian elephant populations are not self-sustaining, possibly due in part to obesity-related health...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (14): jeb228379.
Published: 22 July 2020
... a reduction in glycogen stores yet increase flight activity without changing rates of glycogen depletion. Drosophila Energy Metabolism Obesity Plasticity Protein Glycogen is a critical store of energy for supplying the energetic demands of locomotion in many animals ( Hochachka, 1985...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (11): jeb218974.
Published: 4 June 2020
... and energy homeostasis. Further, the gut microbiota have also been implicated in thermogenesis and obesity. In the present study, we tested the hypothesis that thermo-TRPs and gut microbiota are involved in reducing diet-induced obesity (DIO) during low temperature exposure. C57BL/6J mice in obese (body mass...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (5): jeb188508.
Published: 1 March 2019
...Rudolf J. Schilder; Hannah Stewart ABSTRACT We previously demonstrated the existence of a naturally occurring metabolic disease phenotype in Libellula pulchella dragonflies that shows high similarity to vertebrate obesity and type II diabetes, and is caused by a protozoan gut parasite. To further...
Journal Articles
J Exp Biol (2018) 221 (Suppl_1): jeb167254.
Published: 7 March 2018
...John R. Speakman; Raul K. Suarez; Hans H. Hoppeler ABSTRACT Human obesity has a large genetic component, yet has many serious negative consequences. How this state of affairs has evolved has generated wide debate. The thrifty gene hypothesis was the first attempt to explain obesity as a consequence...
Journal Articles
J Exp Biol (2016) 219 (2): 259–265.
Published: 1 January 2016
...Lena Cron; Tamara Allen; Mark A. Febbraio; Stan L. Lindstedt; Hans H. Hoppeler ABSTRACT It is well known that obesity is responsible, at least in part, for the increased incidence of chronic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Despite public...
Journal Articles
J Exp Biol (2015) 218 (1): 50–58.
Published: 1 January 2015
... and disease’ (DOHaD) is at stake and therefore requires a paradigm shift. Maternal obesity and malnutrition predispose offspring to develop metabolic syndrome, a vicious cycle leading to transmission to subsequent generation(s), with differences in response and susceptibility according to the sex...
Journal Articles
J Exp Biol (2013) 216 (17): 3215–3221.
Published: 1 September 2013
... and inflammation during a condition of ‘natural adiposity’, despite the presence of systemic RAS activation, and comparing this condition with obesity-related pathological conditions in humans has the potential to contribute to the development of effective therapeutic approaches for metabolic syndromes...
Journal Articles
J Exp Biol (2011) 214 (9): 1523–1532.
Published: 1 May 2011
.... For a subset of the Tnnt3 splice forms, obese Zucker rats failed to make the same adjustments; that is, they did not show the same relationship between body weight and the relative abundance of five Tnnt3 β splice forms (i.e. Tnnt3 β2–β5 and β8), four of which showed significant effects on nocturnal energy...
Includes: Supplementary data
Journal Articles
J Exp Biol (2008) 211 (19): 3103–3110.
Published: 1 October 2008
.... Here we show that mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor, leads to abnormal accumulation of both lipid and carbohydrate. As a consequence of their obese phenotypes, AKHR mutants are markedly starvation resistant. We show...
Journal Articles
J Exp Biol (2004) 207 (16): 2859–2866.
Published: 15 July 2004
... ). A novel mechanism of body mass regulation. J. Exp. Biol. 204 , 1729 -1734. Berthoud, H.-R. ( 2002 ). Multiple neuronal systems controlling food intake and body weight. Neurosci. Biobehav. Rev. 26 , 393 -428. Bradley, P. ( 1978 ). The ponderostat and a physiological model of obesity. Am. J...
Journal Articles
J Exp Biol (2002) 205 (15): 2275–2285.
Published: 1 August 2002
...) energy metabolism, which would be consistent with the observations from linkage and association studies. Therefore, UCP2 and UCP3 remain interesting targets for pharmacological upregulation in the treatment of obesity and diabetes. Fig. 1. Action of the electron transport chain leading to the build...