... of non-obese mice ( James et al., 2015 ) and effects of HFD consumption ( Bott et al., 2017 ; Ciapaite et al., 2015 ; Hurst et al., 2018 ; Tallis et al., 2017b ; Hill et al., 2019 ; Eshima et al., 2017 ). For soleus, an aluminium foil T -clip was wrapped around the distal tendon and a small piece...

...Daniella E. Chusyd; Tim R. Nagy; Lilian Golzarri-Arroyo; Stephanie L. Dickinson; John R. Speakman; Catherine Hambly; Maria S. Johnson; David B. Allison; Janine L. Brown ABSTRACT Many captive Asian elephant populations are not self-sustaining, possibly due in part to obesity-related health...

... a reduction in glycogen stores yet increase flight activity without changing rates of glycogen depletion. Drosophila Energy Metabolism Obesity Plasticity Protein Glycogen is a critical store of energy for supplying the energetic demands of locomotion in many animals ( Hochachka, 1985...

... and energy homeostasis. Further, the gut microbiota have also been implicated in thermogenesis and obesity. In the present study, we tested the hypothesis that thermo-TRPs and gut microbiota are involved in reducing diet-induced obesity (DIO) during low temperature exposure. C57BL/6J mice in obese (body mass...

...Rudolf J. Schilder; Hannah Stewart ABSTRACT We previously demonstrated the existence of a naturally occurring metabolic disease phenotype in Libellula pulchella dragonflies that shows high similarity to vertebrate obesity and type II diabetes, and is caused by a protozoan gut parasite. To further...

...John R. Speakman; Raul K. Suarez; Hans H. Hoppeler ABSTRACT Human obesity has a large genetic component, yet has many serious negative consequences. How this state of affairs has evolved has generated wide debate. The thrifty gene hypothesis was the first attempt to explain obesity as a consequence...

...Lena Cron; Tamara Allen; Mark A. Febbraio; Stan L. Lindstedt; Hans H. Hoppeler ABSTRACT It is well known that obesity is responsible, at least in part, for the increased incidence of chronic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Despite public...

... and disease’ (DOHaD) is at stake and therefore requires a paradigm shift. Maternal obesity and malnutrition predispose offspring to develop metabolic syndrome, a vicious cycle leading to transmission to subsequent generation(s), with differences in response and susceptibility according to the sex...

... ). The renin-angiotensin system: a link between obesity, inflammation and insulin resistance . Obes. Rev.   13 , 136 - 149 . Karlsson   C. , Lindell   K. , Ottosson   M. , Sjöström   L. , Carlsson   B. , Carlsson   L. M. S. ( 1998 ). Human adipose tissue expresses angiotensinogen...

.... For a subset of the Tnnt3 splice forms, obese Zucker rats failed to make the same adjustments; that is, they did not show the same relationship between body weight and the relative abundance of five Tnnt3 β splice forms (i.e. Tnnt3 β2–β5 and β8), four of which showed significant effects on nocturnal energy...

.... Here we show that mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor, leads to abnormal accumulation of both lipid and carbohydrate. As a consequence of their obese phenotypes, AKHR mutants are markedly starvation resistant. We show...

... changes in energy balance. * Author for correspondence (e-mail: [email protected] ) 1 6 2004 © The Company of Biologists Limited 2004 2004 body mass set-point energy expenditure body composition ponderostat obesity gravity sex difference mice The set-point theory...

...) energy metabolism, which would be consistent with the observations from linkage and association studies. Therefore, UCP2 and UCP3 remain interesting targets for pharmacological upregulation in the treatment of obesity and diabetes. References Boss, O., Samec, S., Desplanches, D., Mayet, M.-H...

... phase of the daily cycle. The data also highlight the relationship between hypothermia and fat deposition over extended periods in relatively large, endothermic animals and may have some relevance to obesity in humans. * e-mail: [email protected] 17 01 2001 15 03 2001 ©...

...Peter H. Niewiarowski; Michelle L. Balk; Richard L. Londraville ABSTRACT Leptin is a hormone that regulates energy expenditure and body mass in mammals, and it has attracted considerable attention because of its potential in treating human obesity. Comprehensive data from both pathological and non...