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Keywords: nitric oxide
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Journal Articles
J Exp Biol (2021) 224 (2): jeb236257.
Published: 26 January 2021
... sensitivity of mitochondrial respiration to nitric oxide (i.e. the NO IC 50 ), and assessed the mitochondrial response to anoxia–reoxygenation (AR). Acute exposure to 20°C increased maximal mitochondrial respiration by ∼55%; however, the mitochondria's complex I respiratory control ratio was 17% lower and ROS...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (2): jeb195198.
Published: 24 January 2019
... exposure to 30 mmHg for 1 h but there was no effect when fish were exposed for a shorter duration to progressive hypoxia. The mechanism of action of Hif-1α, in part, may be through its downstream target, nitric oxide synthase, and its product, nitric oxide. Overall, the effect of each Hif-1α paralog on the...
Includes: Supplementary data
Journal Articles
J Exp Biol (2017) 220 (21): 4035–4046.
Published: 01 November 2017
...-1α gene expression in abdomen and head tissue of nurses would be in line with this hypothesis. Higher expression of antioxidant enzyme genes was observed in foragers, which could explain their low levels of protein carbonylation. No alterations were seen in nitric oxide (NO) levels, suggesting that...
Journal Articles
J Exp Biol (2016) 219 (24): 3875–3883.
Published: 15 December 2016
...Marie N. Hansen; Jon O. Lundberg; Mariacristina Filice; Angela Fago; Nanna M. G. Christensen; Frank B. Jensen ABSTRACT In mammals, treatment with low doses of nitrite has a cytoprotective effect in ischemia/reperfusion events, as a result of nitric oxide formation and S -nitrosation of proteins...
Journal Articles
J Exp Biol (2015) 218 (13): 2015–2022.
Published: 01 July 2015
...Frank B. Jensen; Lucie Gerber; Marie N. Hansen; Steffen S. Madsen ABSTRACT Nitrite secures essential nitric oxide (NO) bioavailability in hypoxia at low endogenous concentrations, whereas it becomes toxic at high concentrations. We exposed brown trout to normoxic and hypoxic water in the absence...
Journal Articles
J Exp Biol (2015) 218 (14): 2180–2189.
Published: 01 July 2015
... nitric oxide Myoglobin (Mb) is an oxygen binding heme protein expressed primarily in vertebrate skeletal and cardiac muscle where it buffers mitochondrial oxygen availability and facilitates oxygen diffusion ( Salathe and Chen, 1993 ; Gödecke et al., 1999 ; Wittenberg and Wittenberg, 2003...
Includes: Supplementary data
Journal Articles
J Exp Biol (2015) 218 (3): 353–362.
Published: 01 February 2015
... gland or Y-organ (YO). The hypothesis is that nitric oxide (NO), a neuromodulator that controls neurotransmitter release at presynaptic membranes, depresses the frequency and/or amount of MIH pulses to induce molting. NO synthase (NOS) mRNA was present in Carcinus maenas ESG and other tissues and NOS...
Journal Articles
J Exp Biol (2014) 217 (3): 423–431.
Published: 01 February 2014
...Frank B. Jensen; Marie N. Hansen; Gabriella Montesanti; Tobias Wang Moderate elevations of nitrite and nitric oxide (NO) protect mammalian tissues against ischemia (anoxia)-reperfusion damage by inhibiting mitochondrial electron transport complexes and reducing the formation of reactive oxygen...
Journal Articles
J Exp Biol (2013) 216 (14): 2632–2640.
Published: 15 July 2013
... function [phytohemagglutinin-induced cutaneous immune response, antibody production in response to the novel antigen keyhole limpet hemocyanin (KLH), or oxidative burst, assessed by changes in circulating nitric oxide levels], carotenoid-pigmented beak coloration, ovarian development, circulating...
Journal Articles
J Exp Biol (2012) 215 (21): 3813–3822.
Published: 01 November 2012
... the reception of exogenous signals and subsequent endogenous signal transduction. To investigate the involvement of nitric oxide (NO) and cyclic GMP (cGMP) during larval settlement of B. amphitrite , we examined the effects of an NO donor and an NO scavenger, two nitric oxide synthase (NOS) inhibitors...
Includes: Supplementary data
Journal Articles
J Exp Biol (2012) 215 (2): 256–263.
Published: 15 January 2012
... vasodilator nitric oxide (NO), and half the concentration of the serum protein albumin, possibly to compensate for increased blood viscosity. Despite compensation in several hematological and serological parameters, theoretical aerobic dive limits (ADL) were similar between high-elevation and sea-level otters...
Journal Articles
J Exp Biol (2010) 213 (21): 3593–3602.
Published: 01 November 2010
...Marie N. Hansen; Frank B. Jensen SUMMARY Nitric oxide (NO), produced by nitric oxide synthases (NOS enzymes), regulates multiple physiological functions in animals. NO exerts its effects by binding to iron (Fe) of heme groups (exemplified by the activation of soluble guanylyl cyclase) and by S...
Journal Articles
J Exp Biol (2010) 213 (18): 3081–3103.
Published: 15 September 2010
... that is gaining support, particularly among human cardiologists. The actions of CA, NP and CgA, we argue, may be viewed as a hallmark of the cardiac capacity to organize ‘whip-brake’ connection-integration processes in spatio-temporal networks. The involvement of the nitric oxide synthase (NOS)/nitric...
Journal Articles
J Exp Biol (2010) 213 (16): 2726–2733.
Published: 15 August 2010
... substantially contributes to nitric oxide (NO) homeostasis in the heart. By a dynamic cycle, in which a decrease in tissue O 2 tension drives the conversion of Mb from being a NO scavenger under normoxia to a NO producer during hypoxia, mitochondrial respiration is reversibly adapted to the intracellular O 2...
Journal Articles
J Exp Biol (2010) 213 (16): 2734–2740.
Published: 15 August 2010
..., multiple studies have extended our understanding of its occurrence, properties and functions. Beyond the two major roles, the storage and the facilitation of dioxygen diffusion, recent physiological studies have revealed that myoglobin acts as a potent scavenger of nitric oxide (NO • ) representing a...
Journal Articles
J Exp Biol (2010) 213 (16): 2865–2872.
Published: 15 August 2010
... concentration of nitric oxide (NO) metabolites in their plasma compared with that of control animals, indicating that corporeal levels of NO are higher in anemic animals than in control fish. The activity of nitric oxide synthase (NOS) was measured in brain, retina, pectoral muscle and ventricle of control and...
Journal Articles
J Exp Biol (2010) 213 (13): 2310–2321.
Published: 01 July 2010
... chromatography–mass spectrometry (HPLC–MS) analysis, immunocytochemistry and pharmacological manipulations, we tested the role of the diffusible amino acids glutamate and γ-aminobutyric acid (GABA) and a short-lived diffusible gas, nitric oxide (NO), in triggering or modulating contractions in Ephydatia muelleri...
Includes: Multimedia, Supplementary data
Journal Articles
J Exp Biol (2010) 213 (9): 1464–1470.
Published: 01 May 2010
... diapause terminates and embryos resume development. The regulation of diapause termination and post-diapause development is poorly understood at the molecular level, prompting this study on the capacity of hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO) to control these processes. Exposure to H 2 O 2...
Journal Articles
J Exp Biol (2009) 212 (21): 3387–3393.
Published: 01 November 2009
...-dependent release of ATP from RBCs, which stimulates production of nitric oxide (NO) and other vasodilators in the endothelium; (2) release of vasoactive NO from S -nitroso-Hb upon deoxygenation; and (3) reduction of naturally occurring nitrite to vasoactive NO by deoxygenated Hb. This Commentary inspects...
Journal Articles
J Exp Biol (2009) 212 (7): 954–960.
Published: 01 April 2009
...Mikkel Misfeldt; Angela Fago; Hans Gesser SUMMARY Nitric oxide (NO) may influence cardiac mechanical performance relative to O 2 consumption by depressing respiration rate and by affecting the excitation–contraction coupling. Such effects of NO should be particularly important during hypoxia in...