... increase. Morphological measurements revealed a robust increase in the size-independent packing of myofibrillar matrix material occurring with the functional improvement, with just 48.1±5.5% of the cross-sectional area filled with myofibrils at postnatal day 1 whereas 92.5±0.9% was filled by day 28...

... expression,α- actin was the first structural gene to be switched on at the 16-somite stage, followed by myosin heavy chain, troponin T, troponin I and muscle creatine kinase. The final mRNA in the series to be expressed was troponin C . All genes were switched on prior to myofibril assembly. The troponin C...

... muscle structure metabolism intracellular myofibril diffusion glycolysis channelling kinetics regulation creatine kinase Muscle fibers, specialized for the conversion of chemical energy into mechanical work, are some of the most highly structured cells known. Muscles perform diverse...

... of these enzymes has an identical pattern of localization. In mutants null for GPDH,localization of none of the other enzymes occurs and therefore is interdependent. In optimally fixed preparations of myofibrils, accumulation of the enzymes at M-lines is much greater than at Z-discs. However, localization at M...

... Limited 2003 2003 mitochondria myofibril sarcoplasmic reticulum cardiomyocyte mitochondrial respiration muscle intracellular energetic unit In spite of intensive studies, the intracellular mechanisms of regulation of mitochondrial function in heart and skeletal muscle are still obscure...