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Keywords: mitochondria
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Journal Articles
J Exp Biol (2021) 224 (18): jeb242634.
Published: 22 September 2021
... confirmed the involvement of K ATP in mitochondria with TMRE imaging, as hypoxia rapidly (<5 min) depolarized mitochondria in a mK ATP channel-sensitive manner. We conclude that mK ATP channels initiate a neuroprotective pathway in goldfish HCs to maintain [Ca 2+ ] i and avoid excitotoxicity in hypoxia...
Journal Articles
J Exp Biol (2021) 224 (17): jeb215764.
Published: 06 September 2021
.... and Bouillaud , F. ( 2015 ). Oxidation of H 2 S in mammalian cells and mitochondria . Methods Enzymol. 554 , 201 - 228 . 10.1016/bs.mie.2014.11.042 Ahn , B.-H. , Kim , H.-S. , Song , S. , Lee , I. H. , Liu , J. , Vassilopoulos , A. , Deng , C.-X. and Finkel , T...
Journal Articles
J Exp Biol (2021) 224 (17): jeb242745.
Published: 03 September 2021
..., indicating the important role of acclimation in their capacity to adjust to thermal challenges. Climate change Mitochondria Reactive oxygen species Aquatic ectotherms Thermal sensitivity Metabolism Groupe de Recherche Interuniversitaire en Limnologie Natural Sciences...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (10): jeb242279.
Published: 01 June 2021
... respirometry on isolated iBAT mitochondria using substrates and inhibitors targeted to UCP-1. We found that rates of NST increased with cold hypoxia acclimation but only in highland deer mice. There was no effect of cold hypoxia acclimation on iBAT mass in any group, but highland deer mice showed increases...
Journal Articles
J Exp Biol (2021) 224 (9): jeb242382.
Published: 30 April 2021
...Jakob Michaelsen; Angela Fago; Amanda Bundgaard ABSTRACT Mitochondria provide cellular energy through oxidative phosphorylation, and thus temperature-induced constraints on mitochondrial function may be crucial to animal aerobic scope and thermal tolerance. Here, we report the effect of temperature...
Journal Articles
J Exp Biol (2020) 223 (21): jeb233684.
Published: 04 November 2020
... to conserve oxygen. The aim of the present study was to determine in vitro whether skeletal muscle mitochondria become more ‘thermogenic’ to sustain heat production or more ‘economical’ to conserve oxygen in sea-acclimatized immature penguins (hereafter ‘immatures’) compared with terrestrial juveniles. Rates...
Journal Articles
J Exp Biol (2020) 223 (20): jeb227801.
Published: 27 October 2020
... of mitochondrial processes, as mitochondria play a crucial role in animals as the primary site of ATP production. Conventional measures of mitochondrial performance suggest that these organelles can function at temperatures much higher than those that limit whole-organism function, suggesting...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (15): jeb222513.
Published: 04 August 2020
... of natural stressful developmental conditions reveals that glucocorticoid hormones induce telomere shortening by decreasing mitochondrial efficiency without altering oxidative stress, suggesting that telomeres are costly to maintain. Mitochondria Metabolism Proton leak Oxidative stress Telomere...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (12): jeb223776.
Published: 17 June 2020
..., and that 90% of CI is found in this highly stable SC. Interestingly, the presence of stable SCs did not prevent mitochondrial H 2 O 2 production and was not associated with elevated respiration rates of mitochondria isolated from the examined species. Together, these data show that SC stability varies among...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (2): jeb215921.
Published: 29 January 2020
... such as freshwater mussels. However, some species seem to thrive more than others in face of temperature-related stressors. Thermal tolerance may, for example, explain the success of invasive species. It is also known that mitochondria can play a key role in setting an ectothermic species' thermal tolerance...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (18): jeb203687.
Published: 18 September 2019
... of new feeding strategies, such as nutritional programming, to optimize the nutrition and health of farmed fish. Fish Mitophagy Mitochondria ER stress DNA and histone methylation Nutritional programming For more than 20 years, it has been widely accepted that nutritional stimuli...
Journal Articles
J Exp Biol (2019) 222 (17): jeb203521.
Published: 03 September 2019
... different rates of migration of genes located in the mitochondria versus the nucleus ( Darling et al., 2014 ). However, to our knowledge there have been no direct studies of how genotypic variation (either mitochondrial or nuclear) might translate into phenotypic variation in this system. There is some...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (11): jeb200410.
Published: 10 June 2019
...Amanda Bundgaard; Klaus Qvortrup; Lene Juel Rasmussen; Angela Fago ABSTRACT Mitochondria are important to cellular homeostasis, but can become a dangerous liability when cells recover from hypoxia. Anoxia-tolerant freshwater turtles show reduced mitochondrial respiratory capacity and production...
Journal Articles
J Exp Biol (2019) 222 (6): jeb191353.
Published: 18 March 2019
... function. Few species can survive prolonged periods of hypoxia and anoxia at tropical temperatures and those that do may rely on mitochondria plasticity in response to disruptions to oxygen availability. Two carpet sharks, the epaulette shark ( Hemiscyllium ocellatum ) and the grey carpet shark...
Journal Articles
J Exp Biol (2019) 222 (2): jeb189407.
Published: 28 January 2019
... generation among sculpin fishes (Cottidae, Actinopterygii) that are known to vary in whole-animal hypoxia tolerance. We hypothesized that mitochondria from hypoxia-tolerant sculpins would show more efficient O 2 use with a higher phosphorylation efficiency and lower ROS emission. We showed that brain...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (24): jeb186320.
Published: 12 December 2018
... mitochondrial capacity (state III and maximum substrate oxidation capacity), state II membrane potential, proton leak and P/O ratios in northern, but not southern, killifish liver mitochondria. Palmitate-induced mitochondrial uncoupling was detected in northern, but not southern, killifish liver mitochondria...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (17): jeb184713.
Published: 05 September 2018
... of −0.12±0.07 (±95% confidence interval). Likewise, capillary length density (km cm −3 of cardiomyocyte), mitochondrial volume density (fraction of cardiomyocyte) and mitochondrial inner membrane surface density (m 2 cm −3 of mitochondria) also decrease with body mass with exponents of −0.17±0.16, −0.06...
Journal Articles
J Exp Biol (2018) 221 (15): jeb177816.
Published: 13 August 2018
... activities of citrate synthase (CS) and lactate dehydrogenase (LDH), respiration rates of isolated mitochondria, adenylate levels and changes in mitochondrial protein expression were quantified from hearts of animals held at ambient temperature or exposed to their critical thermal maximum (CT max ). Compared...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (8): jeb174391.
Published: 25 April 2018
... and reperfusion causes a burst of mitochondrial reactive oxygen species (ROS) in mammals, the question arises as to whether, and if so how, this ROS burst is prevented in the turtle heart. We find that heart mitochondria isolated from turtles acclimated to anoxia produce less ROS than mitochondria from normoxic...
Journal Articles
J Exp Biol (2018) 221 (7): jeb174466.
Published: 29 March 2018
... mitochondria and liver during post-hatch development. By contrast, elevated dietary DHA had no effect on resting metabolic rate, despite causing significant changes to membrane lipid composition. During cold challenges, higher metabolic rates were achieved by birds that had lower DHA and higher linoleic acid...
Includes: Supplementary data