... as bees transition to foraging. We used transcriptomic and physiological analyses to study whether microRNAs (miRNAs) are involved in the regulation of division of labor. We first identified two miRNAs that showed patterns of expression associated with behavioral maturation, ame-miR-305-5p and ame-miR-375...

... downregulated in skeletal muscle, while ACC1 was unchanged. To explore the regulatory mechanism underlying this hypometabolic state, we used RT-qPCR to examine 55 AMPK-associated microRNAs (miRNAs), which are short non-coding RNA post-transcriptional silencers. We identified changes in 10 miRNAs (three...

...) investigated anoxia-responsive miRNAs in the context of cell cycle regulation, which is known to be inhibited in anoxic turtles ( Fig. 3 ). Protein levels of cyclin D1 (responsible for cell cycle initiation) are down-regulated in anoxia, whereas cyclin D1 transcript levels are unaffected. Deeper investigations...

... Africa. Protein carbonylation, a known marker of DNA damage (hydroxy-2′-deoxyguanosine), and antioxidant capacity did not change following hypoxia but HIF-1 protein levels increased significantly in the brains of two species. Nearly 30 miRNAs known to play roles in hypoxia tolerance were differentially...

... of differentiation at the site of amputation. The temporal expression pattern of the lncRNA, named Neev, closely resembled the pattern of chitin synthase genes, implicated in chaetae formation. We found that the lncRNA has 49 sites for binding a set of four microRNAs (miRNAs) while the chitin synthase 8 mRNA has 478...

...Mary Latimer; Nathalie Sabin; Aurélie Le Cam; Iban Seiliez; Peggy Biga; Jean-Charles Gabillard ABSTRACT In fish, data on microRNAs (miRNAs) involved in myogenesis are scarce. In order to identify miRNAs involved in satellite cell differentiation, we used a methionine depletion/replenishment...

... of environmental exposure, possibly through the action of sex hormones. The expression patterns of miRNA and their susceptibility to environmental exposures is a growing area of research, with only a small number of publications interrogating this epigenetic mechanism. In one of the first studies...

... altered expression of miRNAs that can provide post-transcriptional suppression of mRNA translation and the formation of ribonuclear protein bodies in the nucleus and cytoplasm to allow storage of mRNA transcripts until animals rouse themselves again. Furthermore, mechanisms first identified in epigenetic...