... of metabolic depression. The global metabolomic and enzymatic analyses revealed production of metabolites characteristic of oxygen-independent pathways of ATP generation (lactate and succinate) in the depressed metabolic state, which suggests that anaerobic metabolism was the main energy supply pathway under...

... of metabolic depression. By contrast, fish acclimated to intermittent hypoxia maintained sufficient O 2 transport to support normoxic Ṁ O 2 , modestly recruited lactate metabolism and increased Ṁ O 2 dramatically upon reoxygenation. Both groups of hypoxia-acclimated fish had similar glycogen, ATP...

... of the annual killifish Austrofundulus limnaeus . Developmental arrest Life history evolution Phenotypic plasticity Metabolic depression Summary: Insulin-like growth factor signaling plays a critical role in regulating entrance into embryonic diapause and may determine many of the complex...

.... ( 2000 ). Processes contributing to metabolic depression in hepatopancreas cells from the snail Helix aspersa . J. Exp. Biol.   203 , 3603 - 3612 . Bishop , T. , St-Pierre , J. and Brand , M. D. ( 2002 ). Primary causes of decreased mitochondrial oxygen consumption during metabolic...

... be chronic causes of food limitation through reduced photosynthesis. Furthermore, coral bleaching is common in present-day reefs, creating a context in which metabolic depression could have beneficial value to corals. In the present study, corals (massive Porites spp.) were exposed to an extreme case...

... during diapause and thus alterations in mitochondrial physiology are a key component of the suite of characters associated with cessation of development. Here, we use these two species to illustrate the basic principles of metabolic depression at the physiological and biochemical levels. It is clear...

... by a tremendous number of processes; estimates are that at least 160 known proteins contribute to the regulation of p53 ( Toledo and Wahl, 2006 ). During the winter, hibernating mammals such as ground squirrels oscillate between bouts of metabolic depression (torpor), wherein core body temperature may...

... conditions has been explained largely in the context of two contrasting hypotheses, namely metabolic depression in response to stressful or resource-(e.g. water) limited conditions, or elevation of metabolism at low temperatures to sustain life in extreme conditions. To deconstruct the basis for metabolic...

... doubled in crabs walking for 30 min at 8 m min –1 . The metabolic depression resulting from bacterial injection persisted throughout the exercise period and patterns of phosphagen and adenylate consumption within walking leg muscle were not affected by treatment. The ability of crabs to supply required...

... State University, Columbus,OH 43210, USA 28 3 2009 2009 diapause metabolic depression ecdysone cell cycle lipid metabolism qRT-PCR Many animals living in environments with predictable periods of harsh environmental conditions spend part of their life cycle in a dormant...

... pore metabolic depression anoxia diapause caspase activation © The Company of Biologists Limited 2008 2008 20 3 2008 * Author for correspondence (e-mail: shand@lsu.edu ) Up to 11 different types of cell death have been defined, and the classification of cell death...

... 2007 Eptesicus fuscus fat storing hibernation metabolic depression Myotis lucifugus respirometry thermal preference Limited food availability during winter threatens survival for most temperate-zone mammals; therefore, many species have evolved mechanisms to increase winter...

... long bouts of severe hypoxia or anoxia as a normal part of their developmental environment. Diapausing embryos of A. limnaeus share many metabolic characteristics with other vertebrate facultative anaerobes such as freshwater turtles and crucian carp. A significant metabolic depression (80–90...

.... Their temporal relationship was analysed during the time course of metabolic depression at different ambient temperatures. Body temperature and heart rate were measured in unrestrained dormice with implanted transmitter. Ventilation frequency was monitored by total body plethysmography or infrared video...

... in summer (271μmol O 2 kg -1 min -1 ) than in spring (200μmol O 2 kg -1 min -1 ) and that fasting-induced metabolic depression is only possible in summer (-25% in 14 days). The metabolic rate of rabbits is high at all times (383 μmol O 2 kg -1 min -1 ), but they show a more rapid depression in response...

... from anaerobic metabolism. During hypoxia, a metabolic depression of approximately 2/3 occurred for non-contractile processes in both turtle and trout preparations. During hypoxia, lactate production and residual oxygen consumption were similar in turtle and trout. Cellular energy state...

... =0.75) to values significantly greater than 1.0 in late autumn and during winter dormancy indicates an allometric effect on the degree of metabolic depression related to the size of the fat stores and suggests greater energy conservation in the smaller young. References Abe, A. S. ( 1995...

... metabolic depression during valve closure. * Author for correspondence (e-mail: ortmann@uni-duesseldorf.de ) 11 8 2003 © The Company of Biologists Limited 2003 2003 anaerobiosis bivalve Asian clam Corbicula fluminea calorimetry circadian rhythm metabolic depression energy...

...Julian L. Pakay; Andrew A. Hobbs; Scot R. Kimball; Michael Guppy SUMMARY We have investigated the role of eukaryotic initiation factor 2α(eIF2α) in two estivating organisms previously shown to downregulate protein synthesis during metabolic depression, the land snail Helix aspersa Müller...

... damage during estivation may have resulted from low levels of ROS formation associated with decreased rates of lipid hydroperoxide detoxification and oxidized protein turnover caused by metabolic depression. The regulation of the antioxidant system during hypometabolism may constitute a mechanism...