... of metabolic depression. The global metabolomic and enzymatic analyses revealed production of metabolites characteristic of oxygen-independent pathways of ATP generation (lactate and succinate) in the depressed metabolic state, which suggests that anaerobic metabolism was the main energy supply pathway under...

... of metabolic depression. By contrast, fish acclimated to intermittent hypoxia maintained sufficient O 2 transport to support normoxic Ṁ O 2 , modestly recruited lactate metabolism and increased Ṁ O 2 dramatically upon reoxygenation. Both groups of hypoxia-acclimated fish had similar glycogen, ATP...

... Phenotypic plasticity Metabolic depression The cellular mechanisms that support entrance into reversible states of metabolic and developmental arrest have been studied across a wide range of organisms. There is considerable evidence accumulating that decreases in insulin-like growth factor (IGF...

... by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Although the goldfish's anoxia tolerance results from conserved energy via metabolic depression, its hypoxia tolerance results from exceptional O 2 extraction abilities capable of supporting routine metabolic...

... be chronic causes of food limitation through reduced photosynthesis. Furthermore, coral bleaching is common in present-day reefs, creating a context in which metabolic depression could have beneficial value to corals. In the present study, corals (massive Porites spp.) were exposed to an extreme case...

... during diapause and thus alterations in mitochondrial physiology are a key component of the suite of characters associated with cessation of development. Here, we use these two species to illustrate the basic principles of metabolic depression at the physiological and biochemical levels. It is clear...

... 2 2014 2 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 Torpor Nuclear run-on Metabolic depression During the winter, hibernating mammals such as ground squirrels oscillate between bouts of metabolic depression (torpor), wherein core body temperature may...

... conditions has been explained largely in the context of two contrasting hypotheses, namely metabolic depression in response to stressful or resource-(e.g. water) limited conditions, or elevation of metabolism at low temperatures to sustain life in extreme conditions. To deconstruct the basis for metabolic...

... doubled in crabs walking for 30 min at 8 m min –1 . The metabolic depression resulting from bacterial injection persisted throughout the exercise period and patterns of phosphagen and adenylate consumption within walking leg muscle were not affected by treatment. The ability of crabs to supply required...

.... and Wentworth, S. L. ( 1987 ). Levels of ecdysteroids in diapause and nondiapause eggs of the Australian plague locust, Chortoicetes terminifera (Walker). J. Insect Physiol. 33 , 237 -242. Guppy, M. and Withers, P. ( 1999 ). Metabolic depression in animals: physiological perspectives and biochemical...

...-offs in environmental tolerance may have occurred in parallel with the evolution of diversified pathways for the signaling of cell death in eukaryotic organisms. Many requirements for prolonged metabolic depression have been documented. Gene expression is restricted because the manufacture of new...

... 2007 Eptesicus fuscus fat storing hibernation metabolic depression Myotis lucifugus respirometry thermal preference Limited food availability during winter threatens survival for most temperate-zone mammals; therefore, many species have evolved mechanisms to increase winter...

... in the tolerance of anoxia in A. limnaeus will be to establish the compartmentalization of GABA within the embryo and establish which receptors (if any) are expressed in the various tissues of the embryo. Metabolic depression is supported in most organisms by a coordinated downregulation of energy...

.... Their temporal relationship was analysed during the time course of metabolic depression at different ambient temperatures. Body temperature and heart rate were measured in unrestrained dormice with implanted transmitter. Ventilation frequency was monitored by total body plethysmography or infrared video...

... in summer (271μmol O 2 kg -1 min -1 ) than in spring (200μmol O 2 kg -1 min -1 ) and that fasting-induced metabolic depression is only possible in summer (-25% in 14 days). The metabolic rate of rabbits is high at all times (383 μmol O 2 kg -1 min -1 ), but they show a more rapid depression in response...

... from anaerobic metabolism. During hypoxia, a metabolic depression of approximately 2/3 occurred for non-contractile processes in both turtle and trout preparations. During hypoxia, lactate production and residual oxygen consumption were similar in turtle and trout. Cellular energy state...

... =0.75) to values significantly greater than 1.0 in late autumn and during winter dormancy indicates an allometric effect on the degree of metabolic depression related to the size of the fat stores and suggests greater energy conservation in the smaller young. During dormancy, plasma protein...

... metabolic depression during valve closure. * Author for correspondence (e-mail: [email protected] ) 11 8 2003 © The Company of Biologists Limited 2003 2003 anaerobiosis bivalve Asian clam Corbicula fluminea calorimetry circadian rhythm metabolic depression energy...

...Julian L. Pakay; Andrew A. Hobbs; Scot R. Kimball; Michael Guppy SUMMARY We have investigated the role of eukaryotic initiation factor 2α(eIF2α) in two estivating organisms previously shown to downregulate protein synthesis during metabolic depression, the land snail Helix aspersa Müller...

... damage during estivation may have resulted from low levels of ROS formation associated with decreased rates of lipid hydroperoxide detoxification and oxidized protein turnover caused by metabolic depression. The regulation of the antioxidant system during hypometabolism may constitute a mechanism...