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Keywords: malaria
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Journal Articles
J Exp Biol (2008) 211 (10): 1594–1602.
Published: 15 May 2008
... members of the NAT population in the African malaria mosquito Anopheles gambiae , two of which, AgNAT6 and AgNAT8,preferably transport indole- and phenyl-branched substrates, respectively. The relative expression and distribution of these aromatic NATs were examined with transporter-specific antibodies...
Journal Articles
J Exp Biol (2008) 211 (5): 741–748.
Published: 1 March 2008
... superoxide dismutase (MnSOD) and glutathione S -transferase( Murphy et al., 2003 ), two antioxidants that are closely linked to aging in C. elegans and other organisms ( Sampayo et al.,2003 ; Ayyadevara et al.,2005 ). In mammals, blood insulin levels are altered by malaria parasite infection...
Journal Articles
J Exp Biol (2006) 209 (16): 3183–3198.
Published: 15 August 2006
... action of various NAT members in the amino acid transport network are virtually unexplored. A new transporter, agNAT8, was cloned from the malaria vector mosquito Anopheles gambiae (SS). Upon heterologous expression in Xenopus oocytes it performs high-capacity, sodium-coupled (2:1)uptake of nutrients...
Includes: Supplementary data
Journal Articles
J Exp Biol (2005) 208 (20): 3971–3986.
Published: 15 October 2005
..., we attempted a comprehensive description of the salivary transcriptome of this most important vector of malaria transmission. In addition to many transcripts associated with housekeeping functions, we found an active transposable element, a set of Wolbachia- like proteins, several transcription...
Journal Articles
J Exp Biol (2005) 208 (16): 3211–3218.
Published: 15 August 2005
...Mayumi Akaki; James A. Dvorak SUMMARY Sporozoite invasion of mosquito salivary glands is critical for malaria transmission to vertebrate hosts. After release into the mosquito hemocoel,the means by which malaria sporozoites locate the salivary glands is unknown. We developed a Matrigel-based...
Includes: Multimedia, Supplementary data
Journal Articles
J Exp Biol (2004) 207 (15): 2551–2563.
Published: 1 July 2004
...Mike A. Osta; George K. Christophides; Dina Vlachou; Fotis C. Kafatos SUMMARY The resurgence of malaria is at least partly attributed to the absence of an effective vaccine, parasite resistance to antimalarial drugs and resistance to insecticides of the anopheline mosquito vectors. Novel strategies...
Journal Articles
J Exp Biol (2003) 206 (21): 3735–3744.
Published: 1 November 2003
...Philip J. Rosenthal SUMMARY New drugs against malaria are greatly needed. Many approaches to antimalarial drug discovery are available. These approaches must take into account specific concerns, in particular the requirement for very inexpensive and simple to use new therapies and the need to limit...
Journal Articles
J Exp Biol (2003) 206 (21): 3761–3769.
Published: 1 November 2003
... be required. There are many new strategies and initiatives that, to a greater or lesser degree, will influence how drugs are used. These influences may have a positive or negative effect on reducing malaria morbidity and mortality. The concept of analyzing and monitoring programmatic effectiveness allows...
Journal Articles
J Exp Biol (2003) 206 (21): 3753–3759.
Published: 1 November 2003
...Piero L. Olliaro; Walter R. J. Taylor SUMMARY The emergence and spread of drug-resistant malaria parasites is the major threat to effective malaria control. So far, malaria control has relied heavily on a restricted number of chemically related drugs belonging to either the quinoline...
Journal Articles
J Exp Biol (2003) 206 (21): 3771–3779.
Published: 1 November 2003
...Susanna J. Dunachie; Adrian V. S. Hill SUMMARY Malaria is an intracellular pathogen, for which an effective vaccine is likely to require induction of cell-mediated immunity. Immunisation approaches that stimulate strong and persistent levels of effector T-cells are being sought by many researchers...
Journal Articles
J Exp Biol (2003) 206 (21): 3781–3788.
Published: 1 November 2003
...Siddhartha Mahanty; Allan Saul; Louis H. Miller SUMMARY The use of asexual blood-stage proteins as malaria vaccines is strongly supported by experimental data directly implicating antibodies induced by these antigens in parasite clearance and protection from re-challenge. The selection of blood...
Journal Articles
J Exp Biol (2002) 205 (16): 2429–2451.
Published: 15 August 2002
... salivary gland malaria proteomics transcriptome genomics blood-sucking insect To our knowledge, Table 4 is the first attempt to create a comprehensive catalog of the cDNAs from the A. gambiae salivary gland coding for putative secretory proteins. It is clear from this set of cDNAs...
Journal Articles
J Exp Biol (2001) 204 (23): 4157–4167.
Published: 1 December 2001
...Helge Zieler; David B. Keister; James A. Dvorak; José M. C. Ribeiro SUMMARY Oocyst formation is a critical stage in the development of the malaria parasite in the mosquito. We have discovered that the phospholipase A 2 (PLA2) from the venom of the eastern diamondback rattlesnake ( Crotalus...
Journal Articles
J Exp Biol (2001) 204 (16): 2773–2780.
Published: 15 August 2001
..., of the ovarian follicles at some stage during oogenesis. We have shown that the mosquito Anopheles stephensi responds in this manner when ookinetes of the malaria parasite Plasmodium yoelii nigeriensis first begin to invade the midgut. Little is known about the initiation and regulation of follicle resorption...