...Liqiu Tang; Jinzhen Lv; Xueying Zhang; Chen-Zhu Wang; Dehua Wang ABSTRACT Leptin is a hormone that is secreted by adipocytes and may promote energy expenditure by increasing thermogenesis. Our previous studies have shown that thermo-transient receptor potentials (thermo-TRPs) and gut microbiota...

... and postnatal growth, with implications for lifelong health and disease. Adipose tissue Leptin Pregnancy The process of genomic imprinting results in the monoallelic expression of genes based on their parental origin. This is an epigenetic process because copies of identical deoxyribonucleic acid...

..., cold temperature increased bacterial killing capacity, indicative of innate immunity, and did not affect the mass of the thymus and spleen, intermediate granulocytes, the phytohaemagglutinin (PHA) response and the levels of blood glucose and serum leptin. Corticosterone concentration was affected...

..., indicating that the significant plasticity of digestive physiology increased reproductive performance. Agouti-related protein (AgRP) mRNA expression in the hypothalamus was up-regulated significantly in females raising large litters relative to those raising small litters. Serum leptin levels, and mRNA...

... decreased it by ~4%. SD photoperiod had no effect on reproductive status and leptin levels, whereas LD males increased testes mass and serum testosterone, but the photoperiod had no effect on leptin levels. Vasopressin administration decreased LD-induced reproductive enhancement. Because no consistent...

.... This was associated with upregulated liver gene expression of leptin A1 , leptin A2 , SOCS1 , SOCS2 and SOCS3 , and reduced IGF-I expression. In an in vitro study with liver slices it was shown that recombinant rainbow trout leptin stimulated SOCS1 and SOCS3 expression, but not SOCS2 , IGF-I or genes of enzymes...

... the impact of chronic hypoxia on food intake, the expression of the potent anorexigenic signal leptin and its receptor (lepr), the mRNA levels of key hypothalamic appetite-regulating genes, and the activity of the hypothalamic–pituitary–interrenal (HPI) axis in common carp, Cyprinus carpio . Fish exposed...

... at peak lactation was strongly and negatively associated with the expression of thermogenic genes in BAT. Downregulation of these genes during lactation was correlated with low levels of circulating leptin and high levels of circulating prolactin. Our results are consistent with the HDL theory. However...

... during hypoxia and the role played by the hypoxia-responsive gene leptin. Liver pieces were fixed in 4% paraformaldehyde for 24 h and then the paraformaldehyde was changed and the tissues were fixed again for a further 24 h. Once fixed, the tissues were embedded in paraffin (Tissue Prep 2, Fisher...

...Jian-Guo Cui; Gang-Bing Tang; De-Hua Wang SUMMARY Both pregnancy and lactation are associated with hyperphagia, and circulating leptin levels are elevated during pregnancy but decreased during lactation in Brandt's voles, Lasiopodomys brandtii . Previous findings suggest that impaired leptin...

...Vikas Kumar Roy; Amitabh Krishna SUMMARY The aim of this study was to elucidate the hormonal regulation of leptin synthesis by the white adipose tissue (WAT) during the period of fat accumulation in male Scotophilus heathi . An in vivo study showed a significant correlation between the seasonal...

... endocannabinoid system energy budget leptin non-exercise activity thermogenesis orexin personality wheel running The goal of this review is to provide an overview of the biological control of voluntary exercise and spontaneous physical activity (SPA) in relation to total daily energy expenditure...

...), with and without hormones [IGF-I, leptin and follicle-stimulating hormone (FSH)]. The expression of proliferation and apoptosis markers was evaluated by SDS PAGE–western blotting whereas radioimmunoassay (RIA) measured the release of hormones. High temperature dramatically induced a reduction in both proliferation...

... in their initial photoperiod or transferred to the alternative photoperiod for 8 weeks. Postweaning SD voles had a lower body mass but higher thermogenic capacity compared with LD voles. At the same time, preweaning photoperiod conditions had long-lasting effects on thermogenic capacity later in life. Serum leptin...

... high bone turnover occurred during inactivity. However, bone formation appeared to be balanced with bone resorption. The serum concentration of parathyroid hormone (PTH) was higher in the hibernation( P =0.35) and post-hibernation ( P =0.006) seasons relative to pre-hibernation levels. Serum leptin...

...Peter H. Niewiarowski; Michelle L. Balk; Richard L. Londraville ABSTRACT Leptin is a hormone that regulates energy expenditure and body mass in mammals, and it has attracted considerable attention because of its potential in treating human obesity. Comprehensive data from both pathological and non...