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Keywords: insulin
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Journal Articles
J Exp Biol (2020) 223 (22): jeb226027.
Published: 23 November 2020
... and fitness is less clear. Here, we show that Drosophila exposed to hypoxia during their larval period subsequently show reduced starvation stress resistance and shorter lifespan as adults, with these effects being stronger in males. We find that these effects are associated with reduced whole-body insulin...
Journal Articles
J Exp Biol (2020) 223 (8): jeb213454.
Published: 23 April 2020
...Ayelén M. Blanco; Juan I. Bertucci; José L. Soengas; Suraj Unniappan ABSTRACT This research assessed the direct effects of insulin on nutrient-sensing mechanisms in the brain of rainbow trout ( Oncorhynchus mykiss ) using an in vitro approach. Cultured hypothalamus and hindbrain were exposed to 1...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (13): jeb163840.
Published: 6 July 2018
... chain AMPK HDAC Calcineurin Insulin Work-loop Force Power Ageing Obesity (see Glossary) is a major global health epidemic of the 20th and 21st centuries ( Busutil et al., 2017 ; Hales et al., 2017 ). The World Health Organization defines obesity as abnormal or excessive fat accumulation...
Journal Articles
J Exp Biol (2018) 221 (Suppl_1): jeb161554.
Published: 7 March 2018
.... Mirounga angustirostris Milk Pinniped Insulin Lipolysis Periods of nutrient restriction are common for most free-ranging animals ( Secor and Carey, 2016 ; McCue, 2010 ). Some animals routinely fast (i.e. abstain from nutrient intake) as part of their life history and often display...
Journal Articles
J Exp Biol (2016) 219 (19): 3003–3008.
Published: 1 October 2016
...Carolina Mengoni Goñalons; Marie Guiraud; María Gabriela de Brito Sanchez; Walter M. Farina ABSTRACT Worker honeybees ( Apis mellifera ) carry out multiple tasks throughout their adult lifespan. It has been suggested that the insulin/insulin-like signalling pathway participates in regulating...
Includes: Supplementary data
Journal Articles
J Exp Biol (2016) 219 (18): 2944–2954.
Published: 15 September 2016
... rate and physiological markers of hormonal stress response, energy availability and anaerobic respiration in blood plasma across five ecologically relevant temperatures (24, 28, 32, 35 and 38°C; 3 h exposure). Corticosterone, insulin and glucose concentrations all increased with temperature...
Journal Articles
J Exp Biol (2015) 218 (19): 3083–3090.
Published: 1 October 2015
...Mei-Qin Zhuo; Zhi Luo; Ya-Xiong Pan; Kun Wu; Yao-Fang Fan; Li-Han Zhang; Yu-Feng Song ABSTRACT The influence of insulin on hepatic metabolism in fish is not well understood. The present study was therefore conducted to investigate the effects of insulin on lipid metabolism, and the related...
Journal Articles
J Exp Biol (2013) 216 (10): 1771–1773.
Published: 15 May 2013
...Jun Murakami; Ryuichi Okada; Yutaka Fujito; Manabu Sakakibara; Ken Lukowiak; Etsuro Ito SUMMARY Insulin's action in the brain can directly alter cognitive functioning. We have recently shown that molluscan insulin-related peptides are upregulated following a conditioned taste aversion (CTA...
Journal Articles
J Exp Biol (2013) 216 (3): 492–501.
Published: 1 February 2013
... of neuromuscular signalling whilst the difference between levamisole and aldicarb highlights presynaptic effects. Presynaptic neuromuscular transmission increased between 1 and 5 days old in wild-type but not in the insulin/IGF1 receptor mutant daf-2 ( e1370 ). Intriguingly, there was no evidence of a role...
Journal Articles
J Exp Biol (2013) 216 (2): 208–217.
Published: 15 January 2013
...Anna Drexler; Andrew Nuss; Eric Hauck; Elizabeth Glennon; Kong Cheung; Mark Brown; Shirley Luckhart SUMMARY The highly conserved insulin/insulin-like growth factor (IGF) signaling (IIS) pathway regulates metabolism, development, lifespan and immunity across a wide range of organisms. Previous...
Journal Articles
J Exp Biol (2012) 215 (15): 2696–2702.
Published: 1 August 2012
...Xiao Li Zhao; Ana Regina Campos SUMMARY Whereas the pivotal role of insulin signalling in cell division, growth and differentiation is well documented, its role in the regulation of neuronal function and behaviour has recently become the focus of intense investigation. The simple organization...
Journal Articles
J Exp Biol (2012) 215 (8): 1373–1383.
Published: 15 April 2012
... to different scenarios. In response to fasting, adiponectin expression was up-regulated in adipose tissue, while the expression of its receptors increased in white and red muscle. Insulin injection decreased adipoR1 expression in white and red muscles. We deduce that the adipoRs in trout muscle show opposite...
Journal Articles
J Exp Biol (2011) 214 (9): 1599–1606.
Published: 1 May 2011
... changes in serum insulin level with the circulating leptin level and with the changes in body fat mass in S. heathi . An in vitro study showed insulin induced a significant increase in expression of leptin protein in WAT. The insulin-stimulated increase in leptin expression was associated with increased...
Journal Articles
J Exp Biol (2010) 213 (24): 4151–4157.
Published: 15 December 2010
.... In both cases, fish were implanted with mini-osmotic pumps releasing 0.7 i.u. kg –1 day –1 bovine insulin, and mRNA transcripts and the protein phosphorylation status of proteins controlling glycemia and glucose-related metabolism were studied in fish killed 6 h after the last meal. We demonstrate...
Journal Articles
J Exp Biol (2010) 213 (9): 1443–1452.
Published: 1 May 2010
...Sergio Polakof; Sandrine Skiba-Cassy; Georges Choubert; Stéphane Panserat SUMMARY The relative glucose intolerance of carnivorous fish species is often proposed to be a result of poor peripheral insulin action or possibly insulin resistance. In the present study, data from aortic cannulated rainbow...
Journal Articles
J Exp Biol (2009) 212 (10): 1553–1558.
Published: 15 May 2009
...Chunchun Han; Jiwen Wang; Liang Li; Zhongxian Zhang; Li Wang; Zhixiong Pan SUMMARY In order to obtain some information on how fatty liver arises in geese, we investigated the role of insulin and glucose in triglyceride (TG) accumulation in goose primary hepatocytes. Goose primary hepatocytes were...
Journal Articles
J Exp Biol (2008) 211 (18): 2943–2949.
Published: 15 September 2008
... at the end of the sampling period in all groups. Glucose clearance rates were not significantly different among test groups. A significant insulin response was observed in early lactation, no significant response was observed late in lactation and an intermediate response was observed late in the molt fast...
Journal Articles
J Exp Biol (2008) 211 (15): 2510–2518.
Published: 1 August 2008
... of carbohydrates results in persistent hyperglycemia and impairs post-prandial down regulation of gluconeogenesis despite normal insulin secretion. Since gluconeogenic genes are mainly under insulin control, we put forward the hypothesis that the transcriptional function of insulin as a whole may be impaired...
Journal Articles
J Exp Biol (2008) 211 (5): 741–748.
Published: 1 March 2008
...Mi-Ae Kang; Tiffany M. Mott; Erin C. Tapley; Edwin E. Lewis; Shirley Luckhart SUMMARY Observations from nematodes to mammals indicate that insulin/insulin-like growth factor signaling (IIS) regulates lifespan. As in other organisms, IIS is conserved in mosquitoes and signaling occurs in multiple...
Journal Articles
J Exp Biol (2007) 210 (13): 2346–2351.
Published: 1 July 2007
...Mònica Díaz; Encarnación Capilla; Josep V. Planas SUMMARY In brown trout, red and white skeletal muscle express the insulin-regulatable glucose transporter 4 (btGLUT4). We have previously shown that the mRNA expression of btGLUT4 in red muscle, but not white muscle, is altered under experimental...