...Michael H. Nathanson; Allison Fa. O’Neill; Angela D. Burgstahler ABSTRACT Cytosolic Ca 2+ (Ca i 2+ ) signals begin as polarized, inositol 1,4,5-trisphosphate (InsP3)-mediated Ca i 2+ waves in mammalian epithelia, and this signaling pattern directs secretion together with other cell functions...

... freshwater-adapted animals. The addition of clonidine (1.0 μmol l −1 serosal side) started to inhibit Cl − current after 40–60 s; immediately before this, at 30 s, there was a significant rise ( P <0.05, N =14) in tissue inositol 1,4,5,-trisphosphate (Ins P 3 ) level, but no change at later times...

...Richard J. H. Wojcikiewicz; Stefan R. Nahorski ABSTRACT An extensive group of cell surface receptors are coupled to phosphoinositidase C and thus to the production of the intracellular second messengers inositol 1,4,5-trisphosphate and 1,2-diacylglycerol. While the mechanisms and consequences...