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J Exp Biol (2021) 224 (2): jeb231639.
Published: 18 January 2021
...Shen-Hui Xu; Wei-Wei Fu; Jie Zhang; Hui-Ping Wang; Kai Dang; Hui Chang; Yun-Fang Gao ABSTRACT We previously showed that different skeletal muscles in Daurian ground squirrels ( Spermophilus dauricus ) possess different antioxidant strategies during hibernation; however, the reason for these varied...
J Exp Biol (2019) 222 (19): jeb196493.
Published: 04 October 2019
.... Here, we propose that induced pluripotent stem cells (iPSCs) from unconventional model organisms may retain certain species-specific features that can consequently be investigated in depth in vitro ; we use hibernating mammals as an example. Many species (including ground squirrels, bats and bears) can...
Amanda D. V. MacCannell, Kevin J. Sinclair, Glenn J. Tattersall, Charles A. McKenzie, James F. Staples
J Exp Biol (2019) 222 (4): jeb195750.
Published: 22 February 2019
... mammalian hibernation. In animals housed at constant ambient temperatures (5°C or 25°C, 12 h:12 h light:dark photoperiod), the volume of this depot increased in the autumn and decreased in the spring, suggesting an endogenous circannual pattern. Water-fat MRI revealed that throughout the year this depot is...
Includes: Supplementary data
J Exp Biol (2019) 222 (3): jeb194548.
Published: 01 February 2019
...Amanda D. V. MacCannell; Kevin J. Sinclair; Charles A. McKenzie; James F. Staples ABSTRACT Obligate hibernators express circannual patterns of body mass and hibernation, which persist under constant laboratory conditions. Brown adipose tissue (BAT) is important for thermogenesis during arousals...
J Exp Biol (2018) 221 (Suppl_1): jeb162586.
Published: 07 March 2018
...Mallory A. Ballinger; Matthew T. Andrews; Raul K. Suarez; Hans H. Hoppeler ABSTRACT Brown adipose tissue (BAT) is a unique thermogenic tissue in mammals that rapidly produces heat via nonshivering thermogenesis. Small mammalian hibernators have evolved the greatest capacity for BAT because they use...
J Exp Biol (2018) 221 (4): jeb174508.
Published: 22 February 2018
...Amanda D. V. MacCannell; Ethan C. Jackson; Katherine E. Mathers; James F. Staples ABSTRACT We used electrocardiogram (ECG) telemeters to measure the heart rate of hibernating Ictidomys tridecemlineatus (thirteen-lined ground squirrel). An increase in heart rate from 2.2 to 5 beats min –1 accurately...
Includes: Supplementary data
J Exp Biol (2018) 221 (4): jeb168096.
Published: 19 February 2018
...Elisabeth Rosner; Christian C. Voigt ABSTRACT Mammals fuel hibernation by oxidizing saturated and unsaturated fatty acids from triacylglycerols in adipocytes, yet the relative importance of these two categories as an oxidative fuel may change during hibernation. We studied the selective use of...
J Exp Biol (2018) 221 (1): jeb170894.
Published: 04 January 2018
...Shannon E. Currie; Clare Stawski; Fritz Geiser ABSTRACT Many hibernating animals thermoregulate during torpor and defend their body temperature ( T b ) near 0°C by an increase in metabolic rate. Above a critical temperature ( T crit ), animals usually thermoconform. We investigated the...
J Exp Biol (2017) 220 (16): 2939–2946.
Published: 15 August 2017
...Steven J. Swoap; Gerhard Körtner; Fritz Geiser ABSTRACT The eastern pygmy possum ( Cercartetus nanus ) is a small marsupial that can express spontaneous short bouts of torpor, as well as multi-day bouts of deep hibernation. To examine heart rate ( f H ) control at various stages of torpor in a...
J Exp Biol (2017) 220 (15): 2748–2756.
Published: 01 August 2017
...Jordan Balaban; Emanuel Azizi ABSTRACT Extended periods of skeletal muscle disuse can cause a significant loss of contractile proteins, which compromises the ability to generate force, mechanical work or power, thus compromising locomotor performance. Several hibernating organisms can resist muscle...
Anne-Mari J. Mustonen, Mikko A. J. Finnilä, Katri S. Puukka, Timo J. Jämsä, Simo Saarakkala, Juha K. Tuukkanen, T. Petteri Nieminen
J Exp Biol (2017) 220 (12): 2196–2202.
Published: 15 June 2017
... Fasting Fourier transform infrared imaging Hibernation Nyctereutes procyonoides Based on our current results using pQCT, three-point bending test, µCT, FTIRI and plasma biochemistry, the preservation of bone in wintering raccoon dogs shares similarities with that of bears. The present data...
J Exp Biol (2017) 220 (7): 1181–1186.
Published: 01 April 2017
... respiratory motor processes following cold-submergence. Unlike mammalian hibernators with unloaded limb muscles and inactive locomotor systems, respiratory mechanics of frogs counterintuitively allow for ventilatory maneuvers when submerged. Thus, we hypothesized that bullfrogs generate respiratory motor...
J Exp Biol (2017) 220 (3): 455–459.
Published: 01 February 2017
... evaluated some features of the clotting cascade of black bears, providing novel insights into the underlying mechanisms they evoke for embolic protection during hibernation. We measured activated clotting time, prothrombin time and activated partial thromboplastin time during early denning (December), late...
Includes: Supplementary data
J Exp Biol (2016) 219 (17): 2582–2595.
Published: 01 September 2016
... of disuse and reduced mechanical loading, such as hibernating mammals and aestivating frogs, consistently exhibit limited or no change in musculoskeletal performance. What factors modulate skeletal muscle and bone mass, and what physiological and molecular mechanisms protect against losses of muscle...
Lucas A. Zena, Valter Dantonio, Luciane H. Gargaglioni, Denis V. Andrade, Augusto S. Abe, Kênia C. Bícego
J Exp Biol (2016) 219 (5): 725–733.
Published: 01 March 2016
... merianae ; independent of acclimation, heart rate responds more to hypotension than to hypertension. Adrenergic receptors Baroreceptor Blood pressure Cholinergic tone Hibernation Seasonal changes Baroreflex regulation of arterial blood pressure is important to the maintenance of adequate...
J Exp Biol (2015) 218 (9): 1281–1289.
Published: 01 May 2015
... ), as well as focal adhesion and axon guidance in the brain of hibernating bats ( Biggar and Storey, 2014a ; Kornfeld et al., 2012 ). Another study examining the role of miRNAs in fatty acid metabolism in the adipose tissues of torpid thirteen-lined ground squirrels found that differentially expressed...
J Exp Biol (2015) 218 (1): 150–159.
Published: 01 January 2015
... rate, is a core survival strategy of multiple forms of hypometabolism across the animal kingdom, including hibernation, anaerobiosis, aestivation and freeze tolerance. Global biochemical controls are needed to suppress and reprioritize energy use; one such well-studied control is reversible protein...
Marcus M. Seldin, Mardi S. Byerly, Pia S. Petersen, Roy Swanson, Anne Balkema-Buschmann, Martin H. Groschup, G. William Wong
J Exp Biol (2014) 217 (15): 2667–2679.
Published: 01 August 2014
...Marcus M. Seldin; Mardi S. Byerly; Pia S. Petersen; Roy Swanson; Anne Balkema-Buschmann; Martin H. Groschup; G. William Wong Mammalian hibernation elicits profound changes in whole-body physiology. The liver-derived hibernation protein (HP) complex, consisting of HP-20, HP-25 and HP-27, was shown...
J Exp Biol (2014) 217 (9): 1519–1524.
Published: 01 May 2014
... ( ) during torpor, we simultaneously measured , f H and subcutaneous body temperature ( T sub ) of a hibernator, Gould's long-eared bats ( Nyctophilus gouldi , 9 g, N =18), at ambient temperatures ( T a ) between 0 and 25°C. At rest, f H of normothermic resting bats was negatively correlated with T a , with...
Inge G. Revsbech, Danielle M. Tufts, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Jay F. Storz, Angela Fago
J Exp Biol (2013) 216 (22): 4264–4271.
Published: 15 November 2013
... are compounded in species that are native to high altitude. During hibernation, such species must also contend with vicissitudes of blood gas concentrations and plasma pH caused by episodic breathing. Here, we report an analysis of hemoglobin (Hb) function in six species of marmotine ground squirrels...