... was assessed with a panel of selective inhibitors of inward rectifier channels, the antidiabetic sulphonylureas. All completely inhibited fluid secretion, with IC 50 s of 0.78 mmol l -1 for glibenclamide and approximately 5 mmol l -1 for tolbutamide, 0.01 mmol l -1 for minoxidil and 0.1 mmol l -1 for diazoxide...

...U. I. M. Wiehart; G. Klein; P. Steels; S. W. Nicolson; E. Van Kerkhove SUMMARY The presence of ATP-regulated K + (K ATP) channels in Tenebrio molitor Malpighian tubules was investigated by examining the effect of glibenclamide on both fluid secretion and basolateral membrane potentials (V bl...

... by ouabain revealed no change in K + permeability in crucian carp brain in response to anoxia. Furthermore, superfusing the brain of anoxic crucian carp with the K ATP channel blocker glibenclamide did not alter the efflux rate of K + after glycolysis had been inhibited with IAA. Glibenclamide had no effect...

... in both species; however, activation of these channels with Lemakalim under hypoxic conditions caused the guinea pig heart to respond with an augmented bradycardia similar to that seen in the hypoxic muskrat heart in the absence of drugs. Inhibition of these channels by glibenclamide during hypoxia...

... 1993 © 1993 by Company of Biologists 1993 glibenclamide ATP-sensitive potassium channels hypoxia muskrat heart Ondatra zibethicus The purpose of this study was to perform saturation binding studies on the K ATP channels in several rodent species to determine whether...