...Venus Joumaa; Brian R. MacIntosh; Walter Herzog SUMMARY Force depression observed following active shortening is not well understood. Previous research suggested that force depression might be associated with a stress-induced inhibition of cross-bridges in the newly formed overlap zone following...

...Brad R. Moon; Kevin E. Conley; Stan L. Lindstedt; Michael R. Urquhart SUMMARY Reducing the cost of high-frequency muscle contractions can be accomplished by minimizing cross-bridge cycling or by recycling elastic strain energy. Energy saving by contractile minimization has very different...

...Haruo Sugi; Hiroyuki Iwamoto; Tsuyoshi Akimoto; Hirohiko Kishi SUMMARY We were interested to estimate the maximum mechanical efficiency with which chemical energy derived from ATP hydrolysis is converted into mechanical work by individual cross-bridges when they perform their powerstroke...

...Kenneth P. Murphy; Yan Zhao; Masataka Kawai ABSTRACT Recent advances in protein chemistry and the kinetic analysis of tension transients in skeletal muscle fibres have enabled us to elucidate the molecular forces involved in force generation by cross-bridges. On the basis of the temperature effect...