... in blood osmolality. * Author for correspondence (e-mail: [email protected] ) 5 2 2003 © The Company of Biologists Limited 2003 2003 water effect allostery hagfish Myxine glutinosa hemoglobin bicarbonate osmolality oxygen affinity cooperativity linkage plot...

... be functionally important variation in the genes and pathways that control alternative splicing. Trans-regulatory genes that control alternative splicing are becoming increasingly well characterized [e.g. ( Cooper, 1998 ; Ladd et al., 2001 )], which suggests that there will be opportunities for organismal...

... ) 14 5 2001 © The Company of Biologists Limited 2001 2001 AaIT CNS targeting cooperativity recombinant baculovirus toxin potentiation. Androctomus australis insect toxin (AaIT) is a single-chain neurotoxic polypeptide derived from the venom of the Buthid scorpion...

... been carried out. No evidence for cooperative binding for either effector was detected using these methods. However, isothermal titration calorimetry (ITC) offers a useful tool to gain additional insight into the binding of effectors to these highly allosterically regulated macromolecules. By applying...

...Austen F. Riggs ABSTRACT Cooperative ligand binding by tetrameric vertebrate hemoglobins (Hbs) makes possible the delivery of oxygen at higher pressures than would otherwise occur. This cooperativity depends on changes in dimer–dimer interactions within the tetramer and is reflected in a 50 000...

... urate specific effector binding sites cooperativity Homarus vulgaris The oxygen affinity of many arthropod haemocyanins can be modulated by allosteric effectors. Inorganic ions (H + , Ca 2+ , Mg 2+ , Cl − ) as well as organic compounds (L-lactate, urate, dopamine) can affect haemocyanin...

... at urate concentrations between 0 and 0.93 mmol l −1 and pH7.99±0.03. Cooperativity, expressed as n 50 , was reduced by the presence of both modulators. The influence of the simultaneous presence of both factors on haemocyanin oxygen-affinity was also investigated. The effects of L-lactate and urate...

... and cooperativity for oxygen binding. In accordance with Wyman’s finkage equation, Bohr and Haldane coefficients are found to be identical. Both are pH-independent between pH7 and 8. The changing slopes of the oxygen isobars are likely to reflect changes in cooperativity with pH. Maximum values of n 50 coincide...