[email protected] ) 28 9 2010 © 2011. 2011 sodium channels conotoxins peptides peptidomics Marine cone snails inject prey with paralytic peptide toxins, and more than 500 extant Conus species produce an enormous number of unique Cys-rich conotoxins ( Gray et al., 1988 ; Norton...

... was insensitive to nifedipine at a concentration of 1 μmol l −1 . Pretreatment of the isolated sinus gland containing the intact terminals with a combination of ω-conotoxin (ω-Ctx) GVIA, ω-Ctx MVIIC and ω-agatoxin IVA had no effect on the levels of K + -induced peptide release. * Present address: Biology...

... + current in a dose-dependent manner with no evidence of use-dependence. The calmodulin inhibitors W7 and calmidazolium were ineffective blockers of Na + currents. Crude Conus venoms and the Conus peptides, μ -conotoxin GIIA, μ O-conotoxin MrVIA, w -conotoxin GVIA and ω -conotoxin MVIIC, were without effect...