... – the ‘central limitation’ hypothesis. Experimental evidence from lactating mice exposed to different ambient temperatures allows us to reject this and similar ideas. Two alternative ideas have been proposed. The ‘peripheral limitation’ hypothesis suggests that the maximal sustained energy intake reflects...

... with increases in obesity and inactivity-related morbidity from a variety of diseases, plus possible decreases in psychological quality of life ( Norgan, 1993 ; Booth et al., 2002 ; Castaneda et al., 2005 ). artificial selection central limitation experimental evolution maximum metabolic rate...

... the existence of central limitations in S lines cannot be excluded based solely on the present data, we have previously reported that both S and C lines can attain considerably higher V̇ O 2max during cold exposure in a He-O 2 atmosphere, suggesting that limitations on V̇ O 2max depend on interactions between...

... the physiological limits on sustained metabolic rate:(1) combining peak energy demands to differentiate a central limitation from a peripheral limitation; (2) pushing the animals to their physiological limits(e.g. asymptotic food intake); (3) testing for a central excess capacity (if the limit is set peripherally...