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Keywords: cAMP
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Journal Articles
J Exp Biol (2019) 222 (19): jeb211334.
Published: 10 October 2019
..., adenylate cyclase and cAMP were found to be involved in the β3-AR-dependent downstream transduction pathway. In summary, we show the presence of functional β3-ARs in the goldfish heart, whose activation modulates basal performance and contributes to a hypoxia-dependent increase of contractility...
Journal Articles
J Exp Biol (2018) 221 (4): jeb172866.
Published: 20 February 2018
... of cAMP but not by a phorbol ester. We provide a working model which proposes that 5-HT and cAMP stimulate the vacuolar H + -ATPase of the distal caecum. Our results provide evidence that the gastric caecum is functionally distinct from the adjacent anterior midgut and we discuss possible roles...
Includes: Supplementary data
Journal Articles
J Exp Biol (2017) 220 (3): 425–436.
Published: 01 February 2017
... and intracellular cAMP levels. Interestingly, the V-type H + -ATPase seems to play a role in ammonia retention. A 1 week exposure to 1 mmol l −1 NH 4 Cl (HEA) did not cause a change in ammonia excretion rates, while the three branchial expressed AMTs showed a tendency to be down-regulated. This indicates a shift...
Journal Articles
J Exp Biol (2014) 217 (18): 3377–3385.
Published: 15 September 2014
... in vivo ) was greatest at the anterior ileum, and lowest at the colon. Ileal K + efflux was inhibited by both Scg-AST-6 and Locmi-FGLa/AST-2, with maximal inhibition at 10 −10 and 10 −11 mol l −1 , respectively. Both FGLa/ASTs also inhibited cAMP-stimulated K + efflux from the ileum. Locmi-FGLa/AST-2 also...
Journal Articles
J Exp Biol (2014) 217 (10): 1725–1736.
Published: 15 May 2014
... KN-93. Peptide-induced contractions in the mutants of the phospholipase C-β ( PLC β) gene ( norpA larvae) and in IP 3 receptor mutants were similar to contractions elicited in control larvae. The peptide failed to increase cAMP and cGMP levels in Drosophila body wall muscles. Peptide-induced...
Journal Articles
J Exp Biol (2014) 217 (5): 663–672.
Published: 01 March 2014
...Martin Tresguerres; Katie L. Barott; Megan E. Barron; Jinae N. Roa Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs...
Journal Articles
J Exp Biol (2013) 216 (7): 1225–1234.
Published: 01 April 2013
...-ATPase can be induced immediately after eclosion by way of 8-CPT-cAMP, a membrane-permeant cAMP analogue. (4) 5-HT, however, produces the assembly and activation of V-ATPase only in flies aged for at least 2 h after eclosion, indicating that, at eclosion, the 5-HT receptor/adenylyl cyclase/cAMP...
Includes: Supplementary data
Journal Articles
J Exp Biol (2013) 216 (5): 881–891.
Published: 01 March 2013
... processes linked to V-ATPase activation, but how this is accomplished is still unclear. Here we report that membrane-permeant derivatives of cAMP increase the bafilomycin-sensitive ATPase activity in Malpighian tubules of Aedes aegypti twofold and activate ATP-dependent transport processes. In parallel...
Journal Articles
J Exp Biol (2012) 215 (17): 3028–3036.
Published: 01 September 2012
...Kevin M. Crisp; Brian R. Gallagher; Karen A. Mesce SUMMARY Dopamine (DA) activates fictive crawling behavior in the medicinal leech. To identify the cellular mechanisms underlying this activation at the level of crawl-specific motoneuronal bursting, we targeted potential cAMP-dependent events...
Journal Articles
J Exp Biol (2009) 212 (22): 3612–3620.
Published: 15 November 2009
...Stefanos Dailianis; Efterpi Patetsini; Martha Kaloyianni SUMMARY This study investigated the role of Na + /H + exchanger(NHE) and signalling molecules, such as cAMP, PKC, PI 3-kinase, and immune defence enzymes, NADPH oxidase and nitric oxide synthase, in the induction of protein glutathionylation...
Journal Articles
J Exp Biol (2009) 212 (3): 329–340.
Published: 01 February 2009
... of the V-type H + ATPase is the effect of H89, an inhibitor of PKA,on fluid secretion. H89 reverses the stimulatory effect of AK-III on transepithelial fluid secretion in isolated Malpighian tubules. However,AK-III does not raise intracellular levels of cAMP, the usual activator of PKA, suggesting a cAMP...
Journal Articles
J Exp Biol (2006) 209 (14): 2785–2793.
Published: 15 July 2006
... applied under steady state conditions(perfusion with hemolymph-like saline) produced a transient increase of the transepithelial potential difference ( V te ) from 2.2±0.2 to 4.8±0.3 mV, describing an initial cAMP-dependent stimulating phase followed by an inhibitory phase. Spiperone and domperidone...
Journal Articles
J Exp Biol (2006) 209 (13): 2567–2575.
Published: 01 July 2006
...A. Mishra; K. P. Joy SUMMARY In Heteropneustes fossilis , in vitro incubation of postvitellogenic follicles with 2-hydroxyestradiol-17β(2-OHE 2 , 5 μmol l –1 ) decreased significantly the total cAMP level, concomitant with germinal vesicle breakdown (GVBD). The incubation of the follicles with cAMP...
Journal Articles
J Exp Biol (2006) 209 (3): 531–540.
Published: 01 February 2006
... monophosphate (cAMP) whereas it significantly reduced the intracellular concentration of 3′,5′-cyclic guanosine monophosphate (cGMP). The reduction of cGMP was not observed in the presence of the PKC inhibitor BIM-1. 8-Bromo-cGMP, a membrane-permeable cGMP analogue, reduced the potentiating effect of proctolin...
Journal Articles
J Exp Biol (2005) 208 (23): 4549–4556.
Published: 01 December 2005
... without subsequent addition of ATP and cAMP. CCCP, an uncoupler of the mitochondrial electron-transport chain involved in ATP synthesis, suppressed motility of glycerol-treated sperm, suggesting that ATP synthesis is required for dynein to slide microtubules in glycerol-treated sperm. The amount...
Journal Articles
J Exp Biol (2004) 207 (14): 2507–2518.
Published: 15 June 2004
...(s) mediating dopamine-induced glycoprotein secretion, albumen gland cAMP production and glycoprotein secretion were measured in the presence/absence of selected dopamine receptor agonists and antagonists. Dopamine D1-selective agonists dihydrexidine,6,7-ADTN and SKF81297 stimulated cAMP production...
Journal Articles
J Exp Biol (2004) 207 (5): 743–748.
Published: 15 February 2004
...Erik C. Johnson; Laura M. Bohn; Paul H. Taghert SUMMARY Diuretic hormone 44 (DH) is a bioactive neuropeptide that mediates osmotic balance in a wide variety of insects through increases in cAMP. It is structurally similar to mammalian corticotrophin releasing factor (CRF)peptides. In the moth...
Journal Articles
J Exp Biol (2003) 206 (17): 3007–3014.
Published: 01 September 2003
...C. Vanderlinden; Y. Dewael; J. Mallefet SUMMARY We investigated the effects of cyclic nucleotides (cGMP and cAMP) and inositol triphosphate/diacylglycerol pathways on the KCl-induced luminescence control of the ophiuroid species Amphiura filiformis, Ophiopsila aranea and Ophiopsila californica...
Journal Articles
J Exp Biol (1984) 111 (1): 201–223.
Published: 01 July 1984
...J. W. HANRAHAN; J. E. PHILLIPS The kinetics of 36 C1 fluxes across cAMP-stimulated, short-circuited locust rectum were studied. Raising external K + from 0 to 100 mM increased both K t and V max for net Cl transport (J net Cl ) by four- to six-fold. Hill plots of J net Cl indicated non-cooperative...