...Benjamin N. Harwood; Isabelle Draper; Alan S. Kopin Bursicon is a hormone that modulates wing expansion, cuticle hardening and melanization in Drosophila melanogaster . Bursicon activity is mediated through its cognate G protein-coupled receptor (GPCR), rickets. We have developed a membrane...

... the glycoprotein hormone receptor DLGR2. Although rickets mutants produce and release the insect-tanning hormone bursicon, they do not melanize when injected with extracts containing bursicon. In contrast, mutants do melanize in response to injection of an analog of cyclic AMP, the second messenger for bursicon...

... to suggest a function for this peptide and thus for an identified set of peripheral neurosecretory neurones. 30 8 1988 © 1989 by Company of Biologists 1989 insects peripheral neurosecretory cells bursicon neuropeptides We have discovered a group of three, hitherto undescribed...