.... The total AUC 0→∞ was obtained by summing the two areas. Fractional absorption ( f ), or bioavailability, for each compound was estimated based on the ratio between the area under the curve of plasma concentration versus time for oral administration experiments (AUC oral , in units of min g −1 plasma...

..., and the bioavailability of Fe 3+ and Fe 2+ were compared. In vivo Fe 2+ uptake was significantly greater than Fe 3+ uptake and was reduced by the iron chelator desferrioxamine. Fe 2+ was also more bioavailable than Fe 3+ in in vitro studies that assessed the temporal pattern and concentration-dependency of iron...