... of ATP. Therefore, we hypothesized that GABAergic and/or adenosinergic signalling contributes to the blunted HVR and robust HMR in Damaraland mole-rats. To test this hypothesis, we injected adult animals with saline alone (controls), or 100 mg kg −1 aminophylline or 1 mg kg −1 bicuculline, to block...

... by glycine and GABA, and inhibition occurred at approximately 10-fold lower concentrations compared with tadpoles. The glycine receptor antagonist strychnine (2.5-25.0 μmol l -1 ) and the GABA A receptor antagonist bicuculline (1-10 μmol l -1 )inhibited fictive gill ventilation and increased fictive lung...

... antagonist bicuculline has a paradoxical effect on contractility, stimulating large protracted contractions of the LMBW. The GABA A agonist muscimol potentiates cholinergic contractions of the holothurian LMBW. Another population of GABA receptors is inhibitory and is sensitive to the GABA B agonist baclofen...

... evoked by Mops reversed. Tetraethylammonium (TEA + ) injected into heart interneurones did not block Mops-evoked hyperpolarizations. Mops-evoked outward currents in Retzius cells were partially blocked by d -tubocurarine and bicuculline methiodide, and the latter also partially blocked Mops-evoked...

... with an order of potency muscimol>GABA>isoguvacine. cis -4-aminocrotonic acid (CAC A ), a folded and conformationally restricted GABA analogue, supposed to be diagnostic for the vertebrate GABA C receptor, also induced a bicuculline-resistant chloride current, although with a potency about 10 times lower...

...S. D. Buckingham; B. Hue; D. B. Sattelle ABSTRACT Bicuculline and its methochloride salt block inhibitory postsynaptic potentials recorded from giant interneurone 2 (GI 2) of the cockroach Periplaneta americana following stimulation of cercal nerve X, but fail to block the response to -y...

... sulphonic acid> imidazole-4-acetic acid ≈ β -guanidino proprionic acid ≈5-aminovalerate. In contrast, the antagonist profile differed dramatically: bicuculline, pitrazepin and SR 95103, as well as the channel blocker picrotoxin, were without effect at concentrations up to 10 −4 moll −1...