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Keywords: apoptosis
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Journal Articles
J Exp Biol (2020) 223 (4): jeb217026.
Published: 17 February 2020
... oxygen deficiency but the molecular mechanisms that underlie cellular injury during hypoxia-reoxygenation are not well understood. We examined the molecular markers of autophagy, apoptosis and inflammation during short-term (1 day) and long-term (6 days) hypoxia and post-hypoxic recovery (1 h) in mussels...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (21): jeb186379.
Published: 05 November 2018
... shock protein (HSP) genes were sensitive to temperature exposure, and the expression profiles of most apoptosis-related genes was significantly upregulated at 3 and 48 h under cold and heat stress, respectively. Apoptotic index at 48 h under cold stress was significantly higher than that under heat...
Includes: Supplementary data
Journal Articles
J Exp Biol (2016) 219 (17): 2582–2595.
Published: 01 September 2016
... atrophy may reveal novel regulatory factors and lead to new therapeutics. Aestivation Apoptosis Hibernation Immobilisation Protein synthesis Sclerostin The vertebrate musculoskeletal system executes an array of important functions, including facilitating movement and breathing...
Journal Articles
J Exp Biol (2016) 219 (17): 2673–2686.
Published: 01 September 2016
... appear to induce apoptosis ( Sánchez-Quiles et al., 2010 ), perhaps through greater sensitivity to oxidative damage ( Theiss et al., 2006 ), and the 3′-untranslated region of prohibitin mRNA has been identified as a tumor suppressor with anti-proliferative activity ( Song et al., 2014 ). Based on these...
Includes: Supplementary data
Journal Articles
J Exp Biol (2016) 219 (10): 1476–1487.
Published: 15 May 2016
.... Japanese quail Testis Neural oscillations 5-HTP l -DOPA Apoptosis 5-hyroxytryptophan (5-HTP, a serotonin precursor) and l -dihydroxyphenylalanine ( l -DOPA, a dopamine precursor) administered daily at different intervals are used to induce a specific phase relationship between circadian...
Journal Articles
J Exp Biol (2013) 216 (15): 2813–2820.
Published: 01 August 2013
...Camille W. Paxton; Simon K. Davy; Virginia M. Weis SUMMARY Coral bleaching occurs when there is a breakdown of the symbiosis between cnidarian hosts and resident Symbiodinium spp. Multiple mechanisms for the bleaching process have been identified, including apoptosis and autophagy, and most...
Journal Articles
J Exp Biol (2012) 215 (24): 4308–4313.
Published: 15 December 2012
... to a peptide hormone causes apoptosis in insect haemocytes. * Author for correspondence ( czarniew@amu.edu.pl ) 13 3 2012 29 8 2012 © 2012. 2012 insect haemocytes Neb -colloostatin apoptosis Insect haemocytes engage in immune responses that integrate humoral...
Journal Articles
J Exp Biol (2012) 215 (24): 4267–4277.
Published: 15 December 2012
...Cui-Luan Yao; George N. Somero SUMMARY We investigated the effects of acute heat stress and cold stress on cell viability, lysosome membrane stability, double- and single-stranded DNA breakage, and signaling mechanisms involved in cellular homeostasis and apoptosis in hemocytes of native and...
Journal Articles
J Exp Biol (2009) 212 (23): 3892–3900.
Published: 01 December 2009
... reef sponge shows an extremely high proliferation activity, a short cell cycle duration and massive cell shedding. Cell turnover is predominantly confined to a single cell population, i.e. the choanocytes, and in this process apoptosis only plays a minor role. To our knowledge, such fast cell kinetics...
Journal Articles
J Exp Biol (2008) 211 (19): 3059–3066.
Published: 01 October 2008
... detachment and host cell apoptosis. e-mail: weisv@science.oregonstate.edu 6 8 2008 © The Company of Biologists Limited 2008 2008 coral bleaching symbiosis coral Symbiodinium oxidative stress reactive oxygen species nitric oxide apoptosis Symbioses between a variety...
Journal Articles
J Exp Biol (2008) 211 (15): 2524–2532.
Published: 01 August 2008
... mediator of this effect at an early stage and the NHE1 getting involved at a later time point. Finally, JNKs were found to be the principal mediators of the apoptosis induced under hyperthermic conditions, as their inhibition abolished poly(ADP-ribose)polymerase (PARP) cleavage after 4 h at 42°C. Overall...
Journal Articles
J Exp Biol (2008) 211 (12): 1829–1840.
Published: 15 June 2008
... for correspondence (e-mail: shand@lsu.edu ) 20 3 2008 © The Company of Biologists Limited 2008 2008 apoptosis necrosis permeability transition pore metabolic depression anoxia diapause caspase activation Bioenergetic constraints, as a consequence of metabolic...
Journal Articles
J Exp Biol (2008) 211 (12): 1874–1881.
Published: 15 June 2008
...Michiaki Yamashita; Nanami Mizusawa; Misako Hojo; Takeshi Yabu SUMMARY The pro-apoptotic caspase-3 gene has been shown to have key functions in the execution of apoptosis (programmed cell death) in vertebrate cells. However, the central role of caspase-3 in morphogenesis during development remains...
Journal Articles
J Exp Biol (2008) 211 (9): 1426–1433.
Published: 01 May 2008
... survival with a concomitant appearance of apoptosis in both copepod embryos and female tissues. Concentrations of DD inducing blockage were one order of magnitude lower that those used in classical feeding experiments demonstrating that liposomes are a useful tool to quantitatively analyze the impact of...
Journal Articles
J Exp Biol (2006) 209 (14): 2804–2810.
Published: 15 July 2006
... apoptosis symbiosis Many cnidarians symbiotic with the intracellular dinoflagellate Symbiodinium sp., such as the ecologically important reef-building corals, lose their algal partners in response to a variety of stresses,including exposure to elevated temperature and excessive visible and UV...
Journal Articles
J Exp Biol (2005) 208 (23): 4427–4436.
Published: 01 December 2005
... apoptosis of Mytilus galloprovincialis mantle and gill tissues. The results of our studies revealed that mantle and gill tissues differentially respond to the stressful stimuli examined. In the mantle tissue, 1 μmol l –1 Cu 2+ and 50 μmol l –1 Zn 2+ induced a transient p38-MAPK activation, whereas 1 μmol l...
Journal Articles
J Exp Biol (2005) 208 (22): 4263–4271.
Published: 15 November 2005
... receiving l -arginine ( l -Arg; 2.25%) or N -nitro- l -arginine methyl ester ( l -NAME; 0.01%)as a drinking liquid and maintained at low (4±1°C) or room(22±1°C) temperature for 45 days. Cold generally diminished both iNOS immunopositivity and protein level in IBAT, as well as the rate of apoptosis. Among...
Journal Articles
J Exp Biol (2004) 207 (19): 3369–3380.
Published: 01 September 2004
...I. M. Sokolova; S. Evans; F. M. Hughes SUMMARY Exposure to environmentally prevalent heavy metals such as cadmium can have detrimental effects on a variety of commercially and ecologically important species such as oysters. Since Cd 2+ is known to induce apoptosis in immune cells of vertebrates, we...
Journal Articles
J Exp Biol (2004) 207 (18): 3149–3154.
Published: 15 August 2004
... Limited 2004 2004 brain injury development excitotoxicity apoptosis Perinatal hypoxic–ischemic brain damage is a major cause of acute mortality and chronic neurologic morbidity in infants and children. Statistics suggest an incidence of systemic asphyxia in 2–4 per 1000 full-term births...
Journal Articles
J Exp Biol (2004) 207 (18): 3163–3169.
Published: 15 August 2004
... concentration. Capillary regression, which also occurs over a 3-week period, is accomplished through activation of apoptosis. The implication from these observations is that the brain naturally functions in a low, but controlled, oxygen environment. Acute imbalances in oxygen delivery and metabolic demand are...