... properties in turtle pyramidal neurons similarly. However, acute low temperature exposure lengthens repolarization time, but acclimation to low temperature reverses it. Anoxia tolerance Voltage-gated channels Thermal adaptation Membrane properties Action potential Natural Sciences...

... ( les.buck@utoronto.ca ; ebi.lari@utoronto.ca ) Competing interests The authors declare no competing or financial interests. 22 9 2020 20 4 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: Analysis of pyramidal neurons of anoxia-tolerant goldfish...

... physiological strategies to cope with environmental oxygen deprivation. Mitochondria Anoxia tolerance Succinate Brain Shark Oxygen An adequate and continuous supply of oxygen is fundamental to fuelling vertebrate respiration. If the supply of oxygen is severely diminished in mammalian species...

...://www.biologists.com/user-licence-1-1/ Summary: Prolonged anoxic exposure causes gradual disruption of ATP, ion, water and pH homeostasis, each of which can induce considerable cellular damage in Locusta migratoria . Anoxia tolerance Anoxic stress Ion homeostasis Extracellular potassium Migratory...

... anoxia exposures. MicroRNAs are known to regulate a diverse array of cellular functions required for environmental stress adaptations, and here we explored their role in anoxia tolerance. The tissue-specific anoxia responses observed herein, with 22 anoxia-responsive microRNAs in the hepatopancreas...

... in the anoxia-tolerant painted turtle brain, we investigated the function of taurine as an inhibitory neuromodulator in turtle pyramidal neurons. Using whole-cell patch-clamp electrophysiological methods to record from neurons within a cortical brain sheet, we found that taurine depolarized membrane potential...

...Elisa Tikkanen; Jaakko Haverinen; Stuart Egginton; Minna Hassinen; Matti Vornanen ABSTRACT The effects of sustained anoxia on cardiac electrical excitability were examined in the anoxia-tolerant crucian carp ( Carassius carassius ). The electrocardiogram (ECG) and expression of excitation...

... ), together with catecholamine control, explains tachycardia during recovery from anoxia. Heart rate control Soluble adenylyl cyclase Bicarbonate ions cAMP production Anoxia tolerance Cardiac evolution Hagfishes are extant representatives of the craniate lineage, whose origin dates back 0.5...

... phosphorylation. Recently, we turned our attention to the idea that mechanisms previously associated mainly with epigenetic regulation can also contribute to reversible suppression of gene expression in hypometabolic states. Indeed, situations as diverse as mammalian hibernation and turtle anoxia tolerance show...

... The authors declare no competing financial interests. 24 3 2014 24 6 2014 © 2014. Published by The Company of Biologists Ltd 2014 Reactive oxidative species Pyramidal neurons Whole-cell patch-clamp Anoxia tolerance Channel arrest Calcium Fluorescence Aerobic organisms...

... of the anoxia-tolerant western painted turtle, where a decrease in NMDAR currents is observed with anoxia. This decrease is dependent on a modest rise in cytosolic [Ca 2+ ] ([Ca 2+ ] c ) that is mediated by release from the mitochondria. The aim of this study was to determine whether the mitochondrial...

... hypometabolic states, and stabilize long-term viability during dormancy, are proving to be highly conserved across phylogenic lines. A number of these mechanisms were identified and explored using anoxia-tolerant turtles as the model system, particularly from the research contributions made by Dr Peter L. Lutz...

...Peter L. Lutz; Sarah L. Milton SUMMARY The turtle brain's extraordinary ability to tolerate anoxia is based on constitutive and expressed factors. Constitutive factors that predispose for anoxia tolerance include enhanced levels of glycogen stores, increased densities of protective receptors...

... roles in animal models of anoxia tolerance, freeze tolerance and osmoregulation, and highlights the potential that studies of MAPK pathways have for advancing our understanding of the mechanisms of biochemical adaptation. The ERK module responds primarily to growth factors and mitogens and stimulates...

... of Biologists 1993 red-eared turtle Pseudemys scripta elegans gluconeogenic substrate preference glycogen lactate amino acids anoxia tolerance For animals that routinely undergo periods of prolonged anoxia supported by anaerobic glycolysis (with the accumulation of tissue lactate...