... heart , p38-MAPK activation by copper has a possible protective role through the small Hsp27. References Aggeli, I.-K. S., Gaitanaki, C., Lazou, A. and Beis, I. ( 2001a ). Activation of multiple MAPK pathways (ERKs, JNKs and p38-MAPK) by diverse stimuli in the amphibian heart. Mol. Cell. Biochem...

...Konstantina Stathopoulou; Catherine Gaitanaki; Isidoros Beis SUMMARY We investigated the activation of the p38-MAPK signalling pathway during extracellular pH changes in the isolated perfused amphibian heart. Extracellular alkalosis (pH 8.5 or 9.5) maximally activated p38-MAPK within 2 min (4.17...

...Catherine Gaitanaki; Stathopoulou Konstantina; Stavridou Chrysa; Isidoros Beis SUMMARY We investigated the activation of three subfamilies of MAPKs (ERK, JNKs and p38-MAPK) by oxidative stress in the isolated perfused amphibian heart. Activation of p43-ERK by 100 μmol l -1 H 2 O 2 was maximally...

...-stimulated hearts, a reaction completely blocked by the respective specific antagonists, or the specific p38-MAPK inhibitor SB203580. These findings indicate a functional correlation between p38-MAPK activation and ANP accumulation in the perfused amphibian heart. * Author for correspondence (e...

... ability to maintain pump performance even under extreme conditions. Hearts of ectotherms face a far greater range of environmental variants, such as osmolarity and temperature, than those of endotherms (for reviews, see Driedzic and Gesser, 1994 ; Pinder et al., 1992 ). Thus, the amphibian heart...