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Keywords: ageing
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Journal Articles
J Exp Biol jeb.243875.
Published: 30 January 2023
...Bin-Yan Hsu; Nina Cossin-Sevrin; Antoine Stier; Suvi Ruuskanen Early-life environment is known to affect later-life health and disease, which could be mediated by the early-life programming of telomere length, a key hallmark of ageing. According to the fetal programming of telomere biology...
Journal Articles
J Exp Biol (2022) 225 (21): jeb244915.
Published: 14 November 2022
...Christian König; Bertram Gerber ABSTRACT Memory scores are dynamic across developmental stages. In particular, memory scores typically decrease from late adolescence into old age, reflecting complex changes in mnemonic and sensory-motor faculties, metabolic and motivational changes, and changes...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (12): jeb242465.
Published: 18 June 2021
.... ( 2018 ). Impact of oxidative stress on telomere biology . Differentiation 99 , 21 - 27 . 10.1016/j.diff.2017.12.002 Bateson , M. and Nettle , D. ( 2017 ). The telomere lengthening conundrum - it could be biology . Aging Cell 16 , 312 - 319 . 10.1111/acel.12555...
Includes: Supplementary data
Journal Articles
J Exp Biol (2021) 224 (10): jeb242172.
Published: 24 May 2021
...Geoffrey A. Power; Sean Crooks; Jared R. Fletcher; Brian R. Macintosh; Walter Herzog ABSTRACT We investigated age-related changes to fascicle length, sarcomere length and serial sarcomere number (SSN), and how this affects passive force. Following mechanical testing to determine passive force...
Journal Articles
J Exp Biol (2021) 224 (1): jeb231290.
Published: 6 January 2021
... growth could come at a cost in terms of telomere loss ( Monaghan and Ozanne, 2018 ). Telomeres are repetitive non-coding sequences of DNA located at the ends of chromosomes that maintain genomic integrity and stability ( De Lange et al., 2006 ). Telomeres usually shorten with age, and this shortening...
Journal Articles
J Exp Biol (2020) 223 (23): jeb230185.
Published: 2 December 2020
...Andrew W. McCracken; Eleanor Buckle; Mirre J. P. Simons ABSTRACT Dietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes were recently found to negate lifespan extension by DR, questioning its universal relevance. However, the concept of dietary reaction norms...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (11): jeb224063.
Published: 4 June 2020
... with different maximum lifespan potential (MLSP) and the longer-lived outgroup species Aphyosemion australe were studied to test whether they conform to the predictions of the longevity–homeoviscous adaptation (LHA) theory of ageing. Lipid analyses were performed in whole-fish samples and the peroxidation index...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (2): jeb213785.
Published: 28 January 2020
... to the clearance of a broad spectrum of exogenous and endogenous toxicants and harmful metabolites, including the reactive lipid aldehyde byproducts of lipid peroxidation that are a hallmark of cellular ageing. Here, we tested whether declining transporter functionality may contribute to functional decline...
Journal Articles
J Exp Biol (2019) 222 (24): jeb216176.
Published: 18 December 2019
... stressor affects early postnatal telomere length, linking prenatal conditions to future fitness. We used linear mixed-effects models (LMMs) to test the effect of prenatal exposition to predator cues on incubation time and basal corticosterone levels at day 1 of age. The model included the experimental...
Includes: Supplementary data
Journal Articles
J Exp Biol (2019) 222 (24): jeb207043.
Published: 16 December 2019
... castes may be partially explained by oxidative damage as a result of the diet-induced increase in membrane polyunsaturated fatty acids in workers. Social insect Ageing Plasmalogens Membrane peroxidation index Membrane phospholipids Polyunsaturated fatty acids Apis mellifera Social...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (15): jeb181586.
Published: 10 August 2018
... of Biologists Ltd 2018 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Faster embryonic growth rate, manipulated using incubation temperature, results in shorter telomere length at hatching in a wild bird species, the common tern. Ageing Embryonic development Cell...
Journal Articles
J Exp Biol (2018) 221 (13): jeb163840.
Published: 6 July 2018
... produced per muscle mass. Obesity and ageing have similar physiological consequences. The synergistic effects of obesity and ageing on muscle function may exacerbate morbidity and mortality. Important future research directions include determining: the relationship between time course of weight gain...
Journal Articles
J Exp Biol (2013) 216 (15): 2879–2888.
Published: 1 August 2013
..., oxidants, and aging . Cell   120 , 483 - 495 . Banks   R. , Speakman   J. R. , Selman   C. ( 2010 ). Vitamin E supplementation and mammalian lifespan . Mol. Nutr. Food Res.   54 , 719 - 725 . Barja   G. ( 2007 ). Mitochondrial oxygen consumption and reactive oxygen species...
Includes: Supplementary data
Journal Articles
J Exp Biol (2013) 216 (8): 1388–1397.
Published: 15 April 2013
... of the Glanville fritillary butterfly ( Melitaea cinxia ). Measurements of MR peak showed significant repeatability. Senescence occurred only shortly before death. RMR showed a U-shaped relationship with age and very low repeatability. Intraspecific association between metabolic rates and lifespan was tested under...
Includes: Supplementary data
Journal Articles
J Exp Biol (2013) 216 (3): 492–501.
Published: 1 February 2013
...Ben Mulcahy; Lindy Holden-Dye; Vincent O'Connor SUMMARY Frailty is a feature of neuromuscular ageing. Here we provide insight into the relative contribution of pre- and postsynaptic dysfunction to neuromuscular ageing using the nematode Caenorhabditis elegans . Assays of C. elegans motility...
Journal Articles
J Exp Biol (2012) 215 (7): 1076–1083.
Published: 1 April 2012
...Andreas Behrends; Ricarda Scheiner SUMMARY Honey bees ( Apis mellifera ) are well known for their excellent learning abilities. Although most age groups learn quickly to associate an odor with a sucrose reward, newly emerged bees and old foragers often perform poorly. For a long time, the reason...
Journal Articles
J Exp Biol (2011) 214 (4): 599–606.
Published: 15 February 2011
..., the Ott-Ahlqvist equation was applied. This equation can formulate the effects of multiple serum proteins on COP, according to their molecular mass. The COP values determined in chickens were lower than those previously found in mammals. COP s increased with age in males, and was higher in adult males...
Journal Articles
J Exp Biol (2008) 211 (15): 2492–2501.
Published: 1 August 2008
...Eva E. R. Philipp; Maike Schmidt; Carina Gsottbauer; Alexandra M. Sänger; Doris Abele SUMMARY The decline of cellular and especially mitochondrial functions with age is,among other causes, held responsible for a decrease in physiological fitness and exercise capacity during lifetime. We...
Journal Articles
J Exp Biol (2007) 210 (19): 3407–3414.
Published: 1 October 2007
...Børge Moe; Frédéric Angelier; Claus Bech; Olivier Chastel SUMMARY Ageing is associated with a decline in basal metabolic rate (BMR) in many species, including humans. The evolutionary and physiological causes underlying the relationship between age and BMR are poorly understood. Studies...
Journal Articles
J Exp Biol (2005) 208 (9): 1717–1730.
Published: 1 May 2005
... of body mass(exponent between -0.08 and 0.08). This means that across species a gram of tissue on average expends about the same amount of energy before it dies regardless of whether that tissue is located in a shrew, a cow, an elephant or a whale. This fact led to the notion that ageing and lifespan...