... (body mass and heart ventricle mass, with body mass as a covariate) from a long-term artificial selection experiment for high voluntary wheel-running behavior. In this experiment, all four replicate High Runner (HR) lines reached apparent selection limits around generations 17–27, running approximately...

... that vary in activity level are ambiguous. We hypothesized that high-runner (HR) lines of mice from an experiment that breeds mice for voluntary wheel running would have altered muscle buffering capacity as compared with their non-selected control counterparts. We also expected that 6 days of wheel access...

...Elizabeth M. Dlugosz; Heidi Schutz; Thomas H. Meek; Wendy Acosta; Cynthia J. Downs; Edward G. Platzer; Mark A. Chappell; Theodore Garland, Jr SUMMARY Four lines of mice bred for high voluntary wheel running (HR lines) have high baseline circulating corticosterone levels and increased daily energy...

... voluntary wheel running (HR lines) generally had baseline circulating CORT approximately twofold higher than in four non-selected control (C) lines. To test whether elevated baseline CORT suppresses the inflammatory response in HR mice, we injected females with lipopolysaccharide (LPS). All mice injected...

... cost of wheel running. Most rodent studies also show negative effects of wheel access on body fat, especially in males. Sedentary behaviours per se have not been studied in rodents in relation to obesity. Several lines of evidence demonstrate the important role of dopamine, in addition to other neural...

... –1 , increased 1.5 m min –1 every 2 min)and endurance was measured as the total time or distance run to exhaustion. Blood samples were taken to measure glucose and lactate concentrations at rest during the photophase, during peak nightly wheel running, and immediately following the second endurance...

... 2006 rodent Schistosomatium douthitti metabolic rate liver wheel running phenotypic plasticity Phenotypic plasticity is an important means through which animals respond to unpredictability and stressors in the environment( Fordyce, 2006 ; Schlichting and Pigliucci,1998...