... studies are sparse. Neoformation of capillaries is dependent on endothelial growth factors such as vascular endothelial growth factor (VEGF), a known target gene for hypoxia inducible factor 1 (HIF-1). We hypothesised that prolonged exposure to high altitude increases muscle capillary density...

... governed by the activation of hypoxia-inducible transcription factors (HIF-1, HIF-2), which in turn modulate expression of hypoxically regulated genes such as those encoding vascular endothelial growth factor ( VEGF ) and erythropoietin( EPO ). EPO is a glycoprotein that is produced mainly by interstitial...

... lateral sclerosis (ALS; Cluskey and Ramsden, 2001 ; Rakhit et al., 2002 ). A novel player in the aetiology of ALS has only recently been identified. To study the relevance of HIF-mediated induction of the VEGF-gene, transgenic mice with the hypoxia-responsive element (HRE) deleted were generated...