... suggests a role for Ca 2+ -activated membrane transporters. We demonstrate that the aquaporin inhibitor mercuric chloride reduces the rate of vesicle swelling by an order of magnitude, which suggests that aquaporins facilitate the influx of water during vesicle deployment. Molecular evidence of two...

.... The vesicular GABA transporter (VGAT) is required for the storage of GABA in synaptic vesicles and provides a potentially useful probe for inhibitory circuits. However, specific pharmacologic agents for VGAT are not available, and VGAT knockout mice are embryonically lethal, thus precluding behavioral studies...

... in low-temperature environments. * Author for correspondence (e-mail: [email protected] ) 24 7 2008 © The Company of Biologists Limited 2008 2008 acclimation cold differentiation ionocyte transcriptome transporter Temperature is one of the most important...

...Stanley Caveney; Wendy Cladman; LouAnn Verellen; Cam Donly SUMMARY Selective Na + -dependent re-uptake of biogenic monoamines at mammalian nerve synapses is accomplished by three types of solute-linked carrier family 6 (SLC6) membrane transporter with high affinity for serotonin(SERTs), dopamine...

...Zhilin Liu; Bruce R. Stevens; Daniel H. Feldman; Matthias A. Hediger; William R. Harvey SUMMARY KAAT1, a K + -coupled, neutral amino acid transporter from larval insect midgut, differs from other members of the Na + :neurotransmitter transporter family (SNF) in two important ways: (1) it transports...

...Bruce R. Stevens; Daniel H. Feldman; Zhilin Liu; William R. Harvey SUMMARY CAATCH1 functions both as an amino-acid-gated cation channel and as a cation-dependent, proline-preferring, nutrient amino acid transporter in which the two functions are thermodynamically uncoupled. This study focuses...

... implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across...

...Ayelet Sacher; Adiel Cohen; Nathan Nelson ABSTRACT Transition metals are essential for many metabolic processes, and their homeostasis is crucial for life. Metal-ion transporters play a major role in maintaining the correct concentrations of the various metal ions in living cells. Little is known...

... and characterized at the molecular level in the past 7 years. The transporters constitute three different protein families denoted NaPi-I, NaPi-II and NaPi-III. NaPi-I from the rabbit was the first member of this family to be cloned. However, it still resists efforts to unravel its physiological role and a clear...