... response Proteomics Systems biology Environmental temperature has a ubiquitous effect on rates of biochemical reactions and cellular structures in ectothermic organisms, which have adapted their cellular processes and structures to cope with the specific thermal properties of their habitat...

.... ( 2013 ). How epigenetic mutations can affect genetic evolution: model and mechanism . BioEssays 35 , 571 - 578 . Kohl P. , Crampin E. J. , Quinn T. A. , Noble D. ( 2010 ). Systems biology: an approach . Clin. Pharmacol. Ther. 88 , 25 - 33 . Kupiec J.-J...

... galloprovincialis Mytilus trossulus osmotic stress proteomics salinity stress systems biology Biogeographic distribution ranges of marine organisms are shifting due to climate change, specifically rising atmospheric and oceanic temperatures, increasing acidity of the ocean and more frequent...

... climate change cold stress heat stress Mytilus galloprovincialis Mytilus trossulus proteomics systems biology temperature Temperature strongly affects rates of physiological processes and the integrity of macromolecular structures in cells, and thus plays an important role in limiting...

... galloprovincialis Mytilus trossulus proteomics systems biology temperature Temperature plays an important role in setting limits to the distributions of marine organisms due to its ubiquitous effects on the rates of physiological processes and the integrity of macromolecular cellular structures...

...-mail: [email protected] 16 1 2007 © The Company of Biologists Limited 2007 2007 genetic interactions networks systems biology The relationship between the genotype of an organism and its phenotype is not a simple one-to-one mapping between genes and phenotypes. Rather phenotypes...

... The Company of Biologists Limited 2007 2007 salinity adaptation osmotic stress systems biology euryhaline fish proteomics Major advances in high-throughput technologies for the detection and quantification of nucleic acids, proteins and metabolites have led to a paradigm shift in biological...

... and their interactions,requiring the development of novel methods capable of uncovering cellular organization and functional principles at the systems level. In this review, I aim to show how computational systems biology( Kitano, 2002 ), and more particularly network theory as applied to biological systems, offers...