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Keywords: Senescence
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Journal Articles
J Exp Biol (2021) 224 (15): jeb242218.
Published: 5 August 2021
... , A. G. , Horning , M. , Mellish , J.-A. E. and Lawler , J. M. ( 2009 ). Diving into old age: muscular senescence in a large-bodied, long-lived mammal, the Weddell seal ( Leptonychotes weddellii ) . J. Exp. Biol. 212 , 790 - 796 . 10.1242/jeb.025387 Holt , M. M...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (21): jeb235002.
Published: 6 November 2020
... to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide . Hum. Mol. Genet.   5 , 283 - 292 . 10.1093/hmg/5.2.283 de Magalhães , J. P. and Passos , J. F. ( 2018 ). Stress, cell senescence and organismal ageing . Mech. Ageing...
Includes: Supplementary data
Journal Articles
J Exp Biol (2020) 223 (12): jeb223057.
Published: 17 June 2020
... senescence in this population. Additionally, we detected mixed evidence for a trade-off between reproduction and immune health. * Present address: Biology Department, Luther College, 700 College Drive, Decorah, IA 52101, USA. ‡ Author for correspondence ( jjudson@iastate.edu ) Competing...
Journal Articles
J Exp Biol (2019) 222 (13): jeb194688.
Published: 2 July 2019
... the mechanistic basis of fitness costs. Fourth, I propose the ‘redox signalling hypothesis’ of life history to complement the current ‘oxidative stress hypothesis’ of life history. The latter states that oxidative damage underlies trade-offs because it affects traits like growth, reproduction or cell senescence...
Journal Articles
J Exp Biol (2019) 222 (12): jeb200246.
Published: 25 June 2019
... and accelerated aging. We contrasted markers of oxidative damage with antioxidant profiles across age and sex for propulsive (longissismus dorsi) and maneuvering (pectoralis) muscles of Weddell seals to determine whether previously observed morphological senescence is associated with oxidative stress...
Journal Articles
J Exp Biol (2018) 221 (19): jeb185751.
Published: 8 October 2018
... analyses in other tissues demonstrate that these molecular changes are not generalized markers of senescence, but instead, specific features of the optic glands. Our study expands the classic optic gland–pituitary gland analogy and more specifically, it indicates that, rather than a single ‘self-destruct...
Includes: Supplementary data
Journal Articles
J Exp Biol (2018) 221 (15): jeb181586.
Published: 10 August 2018
... division Life-history trade-off Lifespan Senescence A trade-off between individual growth rate and lifespan is a fundamental prediction from life-history theory, and found across taxa ( Metcalfe and Monaghan, 2003 ; Ricklefs, 2006 ), but the underlying mechanism of this trade-off is poorly...
Journal Articles
J Exp Biol (2018) 221 (14): jeb183228.
Published: 26 July 2018
...Joseph W. Margotta; Stephen P. Roberts; Michelle M. Elekonich ABSTRACT Frequent and highly aerobic behaviors likely contribute to naturally occurring stress, accelerate senescence and limit lifespan. To understand how the physiological and cellular mechanisms that determine the onset and duration...
Journal Articles
J Exp Biol (2015) 218 (5): 668–674.
Published: 1 March 2015
... to irreversible downregulation of antioxidants or telomerase, accelerated telomere loss may even persist beyond the nestling period, exacerbating the effects of early conditions on later-life senescence. An area for future research is to understand the links between telomere loss, oxidative stress and telomerase...
Journal Articles
J Exp Biol (2014) 217 (9): 1437–1443.
Published: 1 May 2014
...Steven J. Lane; W. Anthony Frankino; Michelle M. Elekonich; Stephen P. Roberts The effects of flight behavior on physiology and senescence may be profound in insects because of the extremely high metabolic costs of flight. Flight capacity in insects decreases with age; in contrast, limiting flight...
Journal Articles
J Exp Biol (2013) 216 (15): 2879–2888.
Published: 1 August 2013
... directly causes somatic damage. Oxidative stress, an overproduction of reactive oxygen species in relation to cellular defences, can correlate with reproductive investment and has been implicated as a pathway leading to senescence. This has led to the suggestion that this aspect of physiology could...
Includes: Supplementary data
Journal Articles
J Exp Biol (2013) 216 (9): 1638–1649.
Published: 1 May 2013
... the transition between short-lived and extremely long-lived phenotypes with negligible senescence. Among honey bee workers, short to intermediate lifespans are typical for summer castes, while the winter caste can live up to 10 times longer. For summer castes, experimental interventions could predictably...
Journal Articles
J Exp Biol (2013) 216 (8): 1388–1397.
Published: 15 April 2013
... of the Glanville fritillary butterfly ( Melitaea cinxia ). Measurements of MR peak showed significant repeatability. Senescence occurred only shortly before death. RMR showed a U-shaped relationship with age and very low repeatability. Intraspecific association between metabolic rates and lifespan was tested under...
Includes: Supplementary data
Journal Articles
J Exp Biol (2011) 214 (8): 1322–1332.
Published: 15 April 2011
...Christina C. Tolfsen; Nicholas Baker; Claus Kreibich; Gro V. Amdam SUMMARY Honeybees ( Apis mellifera ) senesce within 2 weeks after they discontinue nest tasks in favour of foraging. Foraging involves metabolically demanding flight, which in houseflies ( Musca domestica ) and fruit flies...
Includes: Supplementary data
Journal Articles
J Exp Biol (2009) 212 (24): 4027–4032.
Published: 15 December 2009
...F. Wolschin; D. Münch; G. V. Amdam SUMMARY Among insects, learning is particularly well studied in the fruit fly Drosophila melanogaster and the honeybee Apis mellifera . A senescence-dependent decline in classic pavlovian conditioning is demonstrated for both species. To understand how aging...
Includes: Supplementary data
Journal Articles
J Exp Biol (2009) 212 (16): 2604–2611.
Published: 15 August 2009
..., while the same fraction of nurses was capable of hovering only in normal air or could not fly at all. Age had a significant effect on MGD (MANCOVA: P <0.001). Because our hypothesis predicted that maximal flight capacity would improve with age in young foragers and senesce in older foragers, we...
Journal Articles
J Exp Biol (2007) 210 (19): 3407–3414.
Published: 1 October 2007
... 2007 Ageing (or senescence) is a decline in physiological functioning with age accompanied by a decrease in reproductive performance and an increase in mortality rate ( Rose, 1991 ; Holmes and Austad, 1995 ). The`rate of living' theory, which arose nearly a century ago( Rubner, 1908 ; Pearl, 1922...
Journal Articles
J Exp Biol (2004) 207 (9): 1523–1532.
Published: 1 April 2004
... (e-mail: buki@ocean.org.il ) 26 1 2004 © The Company of Biologists Limited 2004 2004 apoptosis ascidian Botryllus schlosseri blastogenesis budding epithelial monolayer life extension senescence Blastogenesis, which in some colonial tunicate species is a cyclical...
Journal Articles
J Exp Biol (2003) 206 (24): 4453–4465.
Published: 15 December 2003
... in the periphery and in the central nervous system of cockroaches and stress the importance of multi-level approaches to the study of locomotion. * Author for correspondence (e-mail: alr17@cwru.edu ) 8 9 2003 © The Company of Biologists Limited 2003 2003 senescence walking arthropod...