...Catherine Gaitanaki; Maria Pliatska; Konstantina Stathopoulou; Isidoros Beis SUMMARY In the present study, we investigated the induction of the p38-MAPK signalling pathway by copper, as exemplified by CuCl 2 , in the isolated perfused heart of the amphibian Rana ridibunda . We found that p38-MAPK...

... Rana ridibunda . Previous studies in the mammalian heart have shown that extracellular pH changes by 1.0 unit cause respective alterations in the intracellular pH values by approximately 0.25 units( Fuller et al., 1989 ; Zheng et al., 2005 ). Even though extracellular pH changes of such magnitude...

... or 25μmol l -1 PD98059 during both the equilibration period and the perfusion with either 30 μmol l -1 or 100 μmol l -1 H 2 O 2 for 2 min or 5 min. Frogs ( Rana ridibunda Pallas) weighing 120–150 g were caught in the vicinity of Thessaloniki, Greece and supplied by a local dealer. They were kept...

...Ioanna-Katerina S. Aggeli; Catherine Gaitanaki; Antigone Lazou; Isidoros Beis SUMMARY We investigated the activation of p38-MAPK by various adrenergic agents in the perfused Rana ridibunda heart. Phenylephrine (50 μmol l -1 ) rapidly induced the differential activation of all three mitogen...

...Martha Kaloyianni; Basile Michaelidis; Katerina Moutou ABSTRACT The effects of adenosine and inosine on Rana ridibunda erythrocyte metabolism were studied. Adenosine can be metabolized by Rana ridibunda erythrocytes as a carbon source for glycolysis to maintain ATP levels, whereas neither inosine...