... antimalarial therapies will likely be needed over the coming years, so it is important to pursue multiple strategies for drug discovery. (e-mail: rosnthl@itsa.ucsf.edu ) 2 7 2003 © The Company of Biologists Limited 2003 2003 malaria Plasmodium falciparum drugs chemotherapy drug...

... chloroquine to sulfadoxine/pyrimethamine. This raises the intriguing possibility of rotating antimalarial drugs. (e-mail: cplowe@medicine.umaryland.edu ) 26 6 2003 © The Company of Biologists Limited 2003 2003 Plasmodium falciparum drug resistance PfCRT dihydrofolate reductase...

... countries. In this review we discuss the state of asexual blood-stage vaccines, focusing on recombinant antigens from Plasmodium falciparum . The significance of polymorphism and antigenic variation, the relevance of parasite immune evasion mechanisms, the need for reliable measures of successful...

... or DNA plasmids. Most vaccines are based on attenuated or inactivated whole pathogens or material derived directly from the infectious agent. It is in that context that our recent report summarizing the protection of humans with attenuated Plasmodium falciparum ( Pf ) sporozoites produced at four...

... and with the human parasite Plasmodium falciparum developing in their respective mosquito hosts. The inhibition occurs even in the presence of an irreversible inhibitor of the active site of PLA2, indicating that the hydrolytic activity of the enzyme is not required for the antiparasitic effect. Inhibition is also...