... with downstream transcription factors Smad 2 and Smad 3 ( Brooks et al., 2011 ), suggesting a potential role in increasing protein turnover during interbout arousal periods ( Table 2 ). PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1), a nuclear receptor co-regulator, determines muscle...

...Katharina Bremer; Christopher D. Moyes SUMMARY Mitochondrial content, central to aerobic metabolism, is thought to be controlled by a few transcriptional master regulators, including nuclear respiratory factor 1 (NRF-1), NRF-2 and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α...

... by inhibition of acetyl CoA carboxylase (ACC) after hatching, when ACC protein concentration increases significantly, and by a significant AMPK-induced increase in PGC-1α mRNA concentration (at +1 day), but not in NRF-1 mRNA concentration. AMPK phosphorylation is under the control of thyroid hormone, and AMPK...

... with these studies, scientific investigations into the transcriptional regulation of myoglobin expression have been undertaken. These studies have indicated that activation of key transcription factors (MEF2, NFAT and Sp1) and co-activators (PGC-1α) by locomotor activity, differential intracellular calcium fluxes...

... 1α (PGC-1α), which interacts with a range of transcription factors that control glycolysis, fatty acid oxidation, gluconeogenesis, mitochondrial biogenesis and bioenergetics, and metabolic rate. PGC-1α is best known from mammalian model species but there is increasing evidence that it is also...