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Keywords: PGC-1α
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Journal Articles
J Exp Biol (2016) 219 (2): 226–234.
Published: 1 January 2016
.... Hypometabolism, Torpor Skeletal muscle Atrophy mTOR PGC- When food sources are low and ambient conditions are especially harsh, a number of mammalian species undergo a hypometabolic period with reduced nutrient intake and activity referred to as hibernation. In most animals, this combination...
Journal Articles
J Exp Biol (2011) 214 (11): 1888–1895.
Published: 1 June 2011
...Katharina Bremer; Christopher D. Moyes SUMMARY Mitochondrial content, central to aerobic metabolism, is thought to be controlled by a few transcriptional master regulators, including nuclear respiratory factor 1 (NRF-1), NRF-2 and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-...
Journal Articles
J Exp Biol (2010) 213 (18): 3167–3176.
Published: 15 September 2010
... by inhibition of acetyl CoA carboxylase (ACC) after hatching, when ACC protein concentration increases significantly, and by a significant AMPK-induced increase in PGC- mRNA concentration (at +1 day), but not in NRF-1 mRNA concentration. AMPK phosphorylation is under the control of thyroid hormone, and AMPK...
Journal Articles
J Exp Biol (2010) 213 (16): 2741–2747.
Published: 15 August 2010
... with these studies, scientific investigations into the transcriptional regulation of myoglobin expression have been undertaken. These studies have indicated that activation of key transcription factors (MEF2, NFAT and Sp1) and co-activators (PGC-) by locomotor activity, differential intracellular calcium fluxes...
Journal Articles
J Exp Biol (2009) 212 (18): 2885–2891.
Published: 15 September 2009
... 1α (PGC-), which interacts with a range of transcription factors that control glycolysis, fatty acid oxidation, gluconeogenesis, mitochondrial biogenesis and bioenergetics, and metabolic rate. PGC- is best known from mammalian model species but there is increasing evidence that it is also...