... tissue. Obesity is associated with high body heat content, related to physiological mechanisms resulting in greater heat production and impaired heat loss ( Savastano et al., 2009 ). Despite this, core body temperature is still tightly regulated and may only be subject to a small increase in obese...

...Daniella E. Chusyd; Tim R. Nagy; Lilian Golzarri-Arroyo; Stephanie L. Dickinson; John R. Speakman; Catherine Hambly; Maria S. Johnson; David B. Allison; Janine L. Brown ABSTRACT Many captive Asian elephant populations are not self-sustaining, possibly due in part to obesity-related health...

... a reduction in glycogen stores yet increase flight activity without changing rates of glycogen depletion. Drosophila Energy Metabolism Obesity Plasticity Protein Glycogen is a critical store of energy for supplying the energetic demands of locomotion in many animals ( Hochachka, 1985...

... and energy homeostasis. Further, the gut microbiota have also been implicated in thermogenesis and obesity. In the present study, we tested the hypothesis that thermo-TRPs and gut microbiota are involved in reducing diet-induced obesity (DIO) during low temperature exposure. C57BL/6J mice in obese (body mass...

...Rudolf J. Schilder; Hannah Stewart ABSTRACT We previously demonstrated the existence of a naturally occurring metabolic disease phenotype in Libellula pulchella dragonflies that shows high similarity to vertebrate obesity and type II diabetes, and is caused by a protozoan gut parasite. To further...

...John R. Speakman; Raul K. Suarez; Hans H. Hoppeler ABSTRACT Human obesity has a large genetic component, yet has many serious negative consequences. How this state of affairs has evolved has generated wide debate. The thrifty gene hypothesis was the first attempt to explain obesity as a consequence...

...Lena Cron; Tamara Allen; Mark A. Febbraio; Stan L. Lindstedt; Hans H. Hoppeler ABSTRACT It is well known that obesity is responsible, at least in part, for the increased incidence of chronic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Despite public...

... and disease’ (DOHaD) is at stake and therefore requires a paradigm shift. Maternal obesity and malnutrition predispose offspring to develop metabolic syndrome, a vicious cycle leading to transmission to subsequent generation(s), with differences in response and susceptibility according to the sex...

... of the manuscript. COMPETING INTERESTS No competing interests declared. 10 1 2013 30 4 2013 © 2013. Published by The Company of Biologists Ltd 2013 adiponectin food deprivation insulin resistance obesity renin–angiotensin system tumor necrosis factor-alpha Northern...

.... For a subset of the Tnnt3 splice forms, obese Zucker rats failed to make the same adjustments; that is, they did not show the same relationship between body weight and the relative abundance of five Tnnt3 β splice forms (i.e. Tnnt3 β2–β5 and β8), four of which showed significant effects on nocturnal energy...

.... Here we show that mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor, leads to abnormal accumulation of both lipid and carbohydrate. As a consequence of their obese phenotypes, AKHR mutants are markedly starvation resistant. We show...

.... 26 , 393 -428. Bradley, P. ( 1978 ). The ponderostat and a physiological model of obesity. Am. J. Clin. Nutr. 31 , 1975 -1977. Cabanac, M. ( 2001 ). Regulation and the ponderostat. Int. J. Obes. 25 , Suppl. 5, S7 -S12. Cabanac, M., Dulaux, R. and Spector, N. H. ( 1971 ). Sensory...

...) energy metabolism, which would be consistent with the observations from linkage and association studies. Therefore, UCP2 and UCP3 remain interesting targets for pharmacological upregulation in the treatment of obesity and diabetes. A role for UCP3 in fatty acid metabolism would also be consistent...

... phase of the daily cycle. The data also highlight the relationship between hypothermia and fat deposition over extended periods in relatively large, endothermic animals and may have some relevance to obesity in humans. References Ashwell , C. M. , Czerwinski , S. M. , Brocht , D. M...

...Peter H. Niewiarowski; Michelle L. Balk; Richard L. Londraville ABSTRACT Leptin is a hormone that regulates energy expenditure and body mass in mammals, and it has attracted considerable attention because of its potential in treating human obesity. Comprehensive data from both pathological and non...