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J Exp Biol (2021) 224 (7): jeb240705.
Published: 15 April 2021
..., compared with the ionic composition of the surrounding seawater. We pharmacologically investigated the role of Na + /H + exchangers (NHE) in intracellular pH regulation and midgut proton and sodium maintenance using the NHE inhibitor 5-( n -ethyl- n -isopropyl)amiloride (EIPA). Basolateral EIPA application...
J Exp Biol (2018) 221 (23): jeb186866.
Published: 26 November 2018
... Carbon dioxide Disease vector NHE Rhesus glycoproteins Sodium chloride Like many aquatic invertebrate and vertebrate animals, the larvae of most mosquito species inhabit freshwater systems which can vary remarkably in water chemistry, including in ionic composition and pH ( Patrick et al...
J Exp Biol (2017) 220 (5): 775–786.
Published: 1 March 2017
... + /NH 4 + exchange by the gills, but not the yolk sac skin, of early life stage rainbow trout, possibly resulting from the lack of the key transporter NHE2 in the yolk sac epithelium. Larval fish PNA + ionocyte Na + /H + -exchanger NHE Rhesus glycoproteins Ion regulation...
J Exp Biol (2012) 215 (8): 1337–1345.
Published: 15 April 2012
... cells. * Author for correspondence ( email@example.com ) 19 12 2011 © 2012. 2012 Calliphora vicina salivary gland intracellular pH regulation Na + /H + antiporter NHE vacuolar H + -ATPase V-ATPase intracellular pH insect blowfly BCECF NH 4 Cl prepulse...
J Exp Biol (2012) 215 (7): 1199–1209.
Published: 1 April 2012
... at the apical membrane is accomplished by electroneutral Na + /H + exchange (NHE) via one or more NHE isoforms. The functionality of an apical NHE in low-Na + environments (e.g. <1 mmol l –1 Na + ) is thermodynamically problematic ( Parks et al., 2008 ), but there is increasing evidence of a metabolon...
J Exp Biol (2009) 212 (22): 3612–3620.
Published: 15 November 2009
...Stefanos Dailianis; Efterpi Patetsini; Martha Kaloyianni SUMMARY This study investigated the role of Na + /H + exchanger(NHE) and signalling molecules, such as cAMP, PKC, PI 3-kinase, and immune defence enzymes, NADPH oxidase and nitric oxide synthase, in the induction of protein glutathionylation...
J Exp Biol (2009) 212 (11): 1593–1603.
Published: 1 June 2009
... subfamilies, Na + /H + exchanger (NHE)( Orlowski and Grinstein, 2004 )and NHA ( Brett et al., 2005 ),have orthologs from bacteria to human. The NHE subfamily includes the nine human NHEs that play critical roles in human heart, kidney and stomach( Malo and Fliegel, 2006 ; Orlowski and Grinstein, 2004...
J Exp Biol (2008) 211 (15): 2467–2477.
Published: 1 August 2008
... on NHE expression were investigated. The elevation of plasma cortisol using intraperitoneal implants caused a significant increase in NHE2 mRNA expression without affecting NHE3 mRNA or protein abundance. Thus, we suggest that NHE2 contributes to acid–base regulation during hypercapnia owing to its...
J Exp Biol (2008) 211 (6): 957–968.
Published: 15 March 2008
...; it provides weak HCO 3 – and weaker CO 3 2– anions to the lumen. The cationic pathway consists of H + V-ATPases and Na + /H + antiporters (NHAs), Na + /K + P-ATPases and Na + /H + exchangers (NHEs) along with several(Na + or K + ):amino acid +/– symporters,a.k.a. nutrient amino acid transporters (NATs...
J Exp Biol (2008) 211 (5): 805–815.
Published: 1 March 2008
... concanamycin A; (7) concanamycin A removes alkali-going components from multiphasic 5-HT-induced pH changes; (8) NHE activity and a Cl – -dependent process are involved in generating 5-HT-induced pH changes; (9) the salivary glands probably contain a Na + -driven amino acid transporter. We conclude that V...
Mark R. Rheault, Bernard A. Okech, Stephen B. W. Keen, Melissa M. Miller, Ella A. Meleshkevitch, Paul J. Linser, Dmitri Y. Boudko, William R. Harvey
J Exp Biol (2007) 210 (21): 3848–3861.
Published: 1 November 2007
... this exchange is thought to be mediated by Na + /H + exchanger (NHE)proteins, whose stoichiometry is 1Na + /1H + ; the exchange is therefore electroneutral and is independent of transmembrane voltages. The energy that drives this secondary exchange is provided by the inwardly directed Na + gradient...
J Exp Biol (2007) 210 (13): 2290–2299.
Published: 1 July 2007
.... Hyperosmotic shrinkage by a calculated 25% activated a robust Na influx that in the first 30 min had a strong P O 2 dependency with maximal activation at low P O 2 values and a P 50 of ∼5.5 kPa. This activation was completely abolished by the Na/H exchanger (NHE) inhibitor EIPA (10 –4 mol l -1 ). Hyperosmotic...
J Exp Biol (2007) 210 (8): 1463–1471.
Published: 15 April 2007
... © The Company of Biologists Limited 2007 2007 vacuolar H + -ATPase V-ATPase NHE BCECF intracellular pH dopamine biogenic amines insect cockroach Periplaneta americana salivary glands The epithelial cells forming the ducts in the acinar salivary glands of the cockroach...
J Exp Biol (2005) 208 (2): 345–354.
Published: 15 January 2005
... regulation H + -ATPase Na + /K + -ATPase NHE acid infusion base infusion alkalosis acidosis The gills of marine elasmobranchs are an excellent model for studying the acid-base regulatory mechanism of fishes. While they are the principal acid-base regulatory organs ( Heisler,1988 ), they also...