..., compared with the ionic composition of the surrounding seawater. We pharmacologically investigated the role of Na + /H + exchangers (NHE) in intracellular pH regulation and midgut proton and sodium maintenance using the NHE inhibitor 5-( n -ethyl- n -isopropyl)amiloride (EIPA). Basolateral EIPA application...

... Carbon dioxide Disease vector NHE Rhesus glycoproteins Sodium chloride Like many aquatic invertebrate and vertebrate animals, the larvae of most mosquito species inhabit freshwater systems which can vary remarkably in water chemistry, including in ionic composition and pH ( Patrick et al...

... + /NH 4 + exchange by the gills, but not the yolk sac skin, of early­ life stage rainbow trout, possibly resulting from the lack of the key transporter NHE2 in the yolk sac epithelium. Larval fish PNA + ionocyte Na + /H + -exchanger NHE Rhesus glycoproteins Ion regulation...

... cells. * Author for correspondence ( [email protected] ) 19 12 2011 © 2012. 2012 Calliphora vicina salivary gland intracellular pH regulation Na + /H + antiporter NHE vacuolar H + -ATPase V-ATPase intracellular pH insect blowfly BCECF NH 4 Cl prepulse...

... is not strictly a result of increased MRC fractional area, and other variables, such as differential expression of proteins involved in Na + uptake, must provide C. v. hubbsi with the ability to osmoregulate in dilute freshwater. Another set of inhibitor experiments involved the NHE-specific inhibitor EIPA...

...Stefanos Dailianis; Efterpi Patetsini; Martha Kaloyianni SUMMARY This study investigated the role of Na + /H + exchanger(NHE) and signalling molecules, such as cAMP, PKC, PI 3-kinase, and immune defence enzymes, NADPH oxidase and nitric oxide synthase, in the induction of protein glutathionylation...

... binding and translocation. Based on the crystal structure of NhaA, a model structure of the human Na + /H + exchanger (NHE1) was constructed, paving the way to a rational drug design. * Author for correspondence (e-mail: [email protected] ) 19 11 2008 2009 NhaA NHA NHE Na...

... on NHE expression were investigated. The elevation of plasma cortisol using intraperitoneal implants caused a significant increase in NHE2 mRNA expression without affecting NHE3 mRNA or protein abundance. Thus, we suggest that NHE2 contributes to acid–base regulation during hypercapnia owing to its...

...; it provides weak HCO 3 – and weaker CO 3 2– anions to the lumen. The cationic pathway consists of H + V-ATPases and Na + /H + antiporters (NHAs), Na + /K + P-ATPases and Na + /H + exchangers (NHEs) along with several(Na + or K + ):amino acid +/– symporters,a.k.a. nutrient amino acid transporters (NATs...

... concanamycin A; (7) concanamycin A removes alkali-going components from multiphasic 5-HT-induced pH changes; (8) NHE activity and a Cl – -dependent process are involved in generating 5-HT-induced pH changes; (9) the salivary glands probably contain a Na + -driven amino acid transporter. We conclude that V...

... of British Columbia Okanagan, Kelowna, BC, V1V 1V7, Canada 20 8 2007 © The Company of Biologists Limited 2007 2007 sodium potassium exchanger alkalinization AgNHA NHA AgNHE NHE CHA CHE CPA2 African malaria mosquito All organisms regulate their cellular pH, volume...

.... Hyperosmotic shrinkage by a calculated 25% activated a robust Na influx that in the first 30 min had a strong P O 2 dependency with maximal activation at low P O 2 values and a P 50 of ∼5.5 kPa. This activation was completely abolished by the Na/H exchanger (NHE) inhibitor EIPA (10 –4 mol l -1 ). Hyperosmotic...

... © The Company of Biologists Limited 2007 2007 vacuolar H + -ATPase V-ATPase NHE BCECF intracellular pH dopamine biogenic amines insect cockroach Periplaneta americana salivary glands Intracellular pH (pH i ) affects a plethora of physiological processes, such as cellular...

... H + -ATPase Na + /K + -ATPase NHE acid infusion base infusion alkalosis acidosis The gills of marine elasmobranchs are an excellent model for studying the acid-base regulatory mechanism of fishes. While they are the principal acid-base regulatory organs ( Heisler,1988 ), they also have...

...-potential-sensitive, Na + -accepting ion channel was also demonstrated. The basolateral Na + /H + exchanger physiologically resembles members of the NHE family of Na + /H + antiporters described in vertebrates and departs from the apical electrogenic system previously described in lobster. Whether...

... and basolateral transporters may play significant roles in calcification and heavy metal detoxification. ©The Company of Biologists Limited 1994 Na + /H + exchange antiport electrogenic calcium transport Ca 2+ -ATPase NHE sodium transport Ca 2+ /Na + exchange calcium channel amiloride...