... for the existence of ABCC-like efflux transporters in (gastropod) neurons and reports age-associated decline in the extrusion capacity of these transporters. ABC transporter Lymnaea stagnalis Ageing Lipid peroxidation Probenecid MK-571 Cellular homeostasis, the maintenance of a balanced...

...Hiroshi Sunada; Takayuki Watanabe; Dai Hatakeyama; Sangmin Lee; Jeremy Forest; Manabu Sakakibara; Etsuro Ito; Ken Lukowiak ABSTRACT Cannabinoids are hypothesized to play an important role in modulating learning and memory formation. Here, we identified mRNAs expressed in Lymnaea stagnalis central...

... partially understood. Our investigation, performed on the pond snail Lymnaea stagnalis whose nervous system is useful for work on completely isolated neurons, provided several results related to this problem. First, we demonstrated that the behavioural state can produce long-term changes in individual...

... or financial interests. 29 9 2014 19 1 2015 © 2015. Published by The Company of Biologists Ltd 2015 Summary: Reconsolidation occurs after a memory has been activated. We show here that a combination of stressors can block this process. Lymnaea stagnalis Long-term memory...

... of Lymnaea stagnalis as an invertebrate model to elucidate the effects of flavonoids on cognition. (−)Epicatechin (epi) is a flavonoid present in cocoa, green tea and red wine. We studied its effects on basic snail behaviours (aerial respiration and locomotion), long-term memory (LTM) formation and memory...

...Sarah Dalesman; Ken Lukowiak SUMMARY Social isolation is often considered to have negative effects on cognitive function in a wide range of species. Here we assess how environmental context alters the effect of isolation on long-term memory formation (24 h) in the pond snail Lymnaea stagnalis . We...

...Sarah Dalesman; Vikram Karnik; Ken Lukowiak SUMMARY The great pond snail, Lymnaea stagnalis , is commonly used as a model species to study how stress affects the ability to form long-term memory (LTM); however, we still have little information about how the snail senses stressful stimuli...

... is that forgetting is an active process, whereby the previously learnt response is replaced by new learning that interferes with the older memory. Hence, we hypothesized that an appropriately timed environmental stressor that blocks long-term memory (LTM) formation would also block forgetting. Lymnaea stagnalis (L...

...Richard Stephenson; Vern Lewis SUMMARY The objective of this study was to determine whether the great pond snail, Lymnaea stagnalis , expresses a sleep-like behavioural state. We found that snails spontaneously enter a relatively brief (22±1 min) quiescent state characterized by postural relaxation...

...Hiroshi Sunada; Taichi Sakaguchi; Tetsuro Horikoshi; Ken Lukowiak; Manabu Sakakibara SUMMARY The shadow-induced withdrawal response in Lymnaea stagnalis is mediated by dermal photoreceptors located on the foot, mantle cavity, and skin around the pneumostome area. Here, we determined whether we...

... invertebrate nervous systems. Remarkably, the invertebrate LCa v 2 channel from the pond snail, Lymnaea stagnalis , does not bear any of the hallmarks of mammalian, voltage-dependent G-protein inhibition of Ca v 2.2. Swapping either the I-II linker or N-terminus of Ca v 2.2, which serve as key binding domains...

.... The effect of oxygen concentration on rotation rates was not as widespread as observed under laboratory conditions, probably because the measured oxygen concentrations were above the range that influences embryonic rotation in the laboratory. The rotational behaviour of laboratory-reared Lymnaea stagnalis...

.... Lymnaea stagnalis (L.) is considered a calciphile and exhibits reduced growth and survival in environments containing less than 20 mg l −1 Ca 2+ . Many freshwater systems exhibit fluctuations in calcium concentration over time: where calcium levels are normally high there may be periods of low [Ca 2...

... and memory formation in conjunction with predator detection is a form of inducible defense. * Authors for correspondence ( [email protected] ) 30 9 2009 © 2010. Lymnaea stagnalis long-term memory juvenile predator crayfish operant conditioning environmental stressor...

... copulatory behaviour of the pond snail Lymnaea stagnalis (L.) involves eversion (protraction) and retraction of the relatively large penis-carrying organ. For this preputium, protractor and retractor muscle bands have been defined, which implies eversion and retraction through the activity of these muscle...

... that is a necessary site for LTM formation. Here we ask: (1)do distinct populations of wild Lymnaea stagnalis respond only to sympatric predators and if so, can these traits be quantified at both the behavioral and neurophysiological levels, and (2) does the presence of a non-sympatric predator elicit anti-predator...

...Una Cheung; Mehrnoush Moghaddasi; Hannah L. Hall; J. J. B. Smith; Leslie T. Buck; Melanie A. Woodin SUMMARY To characterize the effect of severe hypoxia on neuronal activity,long-term intracellular recordings were made from neurones in the isolated central ring ganglia of Lymnaea stagnalis . When...

..., Lymnaea stagnalis . Respiratory behavior can be operantly conditioned and extinguished in Lymnaea , and this behavior is dependent on a critical dopamine neuron. We tested the hypothesis that repeated cocaine exposure promotes learning and memory or attenuates the ability to extinguish the memory...

...Rio Sugai; Hatsuki Shiga; Sachiyo Azami; Takayuki Watanabe; Hisayo Sadamoto; Yutaka Fujito; Ken Lukowiak; Etsuro Ito SUMMARY Conditioned taste aversion (CTA) in the pond snail Lymnaea stagnalis has been widely used as a model for gaining an understanding of the molecular and behavioral mechanisms...

...M. R. Lowe; G. E. Spencer SUMMARY The aim of this study was to investigate the neural basis of operant conditioning in a semi-intact preparation of the pond snail, Lymnaea stagnalis . Lymnaea learns, via operant conditioning, to reduce its aerial respiratory behaviour in response to an aversive...