... xanthine (IBMX) (EC 50 =69 μmol l −1 ) exerted different effects on the activated conductance. IBMX only sensitized the activated conductance, whereas cyclic AMP (CPTcAMP) at high concentrations induced an increase in anionic conductance that was insensitive to electrical potential. Furthermore, external...

... min) showed essentially complete, homologous desensitisation, and this phenomenon reversed slowly (half-time 6.3±0.9 h). After 10 min of recovery from preincubation in adrenaline, isobutylmethylxanthine (IBMX, 5 mmol l −1 ) had no effect upon the desensitisation and the cells showed no loss...

..., School of Biology, University of Sussex, Brighton, BN1 9QG, UK. 14 4 1993 © 1993 by Company of Biologists 1993 opiate receptors IBMX invertebrate neurones 8-bromo-cyclic AMP Aplysia californica A common response to leucine enkephalin and the stable analogue D-Ala 2...

... injection) could not be measured accurately, but was found to be much greater than the length of the CA. Forskolin- and IBMX-induced elevation of intracellular cAMP increased the electrotonic potential but reduced juvenile hormone release of day 8 CA. REFERENCES Baumann , G. ( 1968 ). Zur...