.... In this study, we examined whether altered temperature during embryonic development results in developmental plasticity in upper thermal tolerance or hypoxia tolerance using a small topminnow, Fundulus heteroclitus , and examined potential underlying molecular mechanisms. We incubated embryos at one of two...

... ) is associated with hypoxia tolerance, ventricle size and myoglobin level . J. Exp. Biol. 216 , 1183 - 1190 . 10.1242/jeb.080556 Anttila , K. , Couturier , C. S. , Overlie , O. , Johnsen , A. , Marthinsen , G. , Nilsson , G. E. and Farrell , A. P. ( 2014 ). Atlantic...

... ). Our results showed that mitochondria of oysters acclimated to high or low salinity did not show severe damage and dysfunction during H/R stress, consistent with the hypoxia tolerance of C. gigas . However, acclimation to low salinity led to improved mitochondrial performance and plasticity, indicating...

... regulators of the endocrine stress response. Hypoxia exposure at 5 dpf also inhibited the cortisol stress response to hypoxia in 10 dpf larvae and increased hypoxia tolerance. However, 10% DO exposure at 5 dpf for 16 h did not affect the cortisol stress response to a novel stressor in 10 dpf larvae...

... for its hypoxia tolerance associated with metabolic rate depression, yet the mechanisms that sustain mitochondrial function during oxygen fluctuations are not well understood. We used top-down metabolic control analysis (MCA) to determine aerobic capacity and control over oxygen flux in the mitochondria...

... in environmental O 2 , and increases in Hif-α (the hypoxia-sensitive subunit of the transcription factor Hif) have been documented in a number of species as a result of a decrease in O 2 . Here, we discuss the impact of the Hif pathway on the hypoxic response and the contribution to hypoxia tolerance, particularly...

... hypoxia tolerance, many fishes cope with warming by adjusting physiological traits through thermal acclimation. Yet, little is known about how such adjustments affect tolerance to hypoxia. We examined European perch ( Perca fluviatilis ) from the Biotest enclosure (23°C, Biotest population), a unique ∼1...

... as an indicator of hypoxia tolerance, is, instead, simply a rate-specific reflection of the oxygen supply capacity. A compensatory reduction in maintenance metabolic costs in warm-adapted species constrains factorial aerobic scope and the critical P O 2 to a similar range, between ∼2 and 6, across each species...

... and specialized defenses against endogenous oxidative stress. However, how the brains of these subterranean mammals handle acute in vivo hypoxia is poorly understood. This study is the first to examine the molecular response to low oxygen in six different species of hypoxia-tolerant mole-rats from sub-Saharan...

... activating kinases IKKα and TBK1. Crassostrea gigas exhibited higher hypoxia tolerance, as well as blunted or delayed inflammatory and apoptotic response to hypoxia and reoxygenation as shown by the later onset and/or the lack of transcriptional activation of caspases, BAX and the inflammatory effector NF-κB...

... generation among sculpin fishes (Cottidae, Actinopterygii) that are known to vary in whole-animal hypoxia tolerance. We hypothesized that mitochondria from hypoxia-tolerant sculpins would show more efficient O 2 use with a higher phosphorylation efficiency and lower ROS emission. We showed that brain...

..., whereas fish acclimated to intermittent hypoxia maintained routine O 2 demands, suggesting that distinct physiological mechanisms can be used to cope with different patterns of hypoxia exposure. Respirometry Hypoxia tolerance Metabolic depression Excess post-hypoxic oxygen consumption...

... pressure ( P crit ), the P O 2 below which oxygen supply cannot match basal demand, is a commonly reported index of hypoxia tolerance. Any CO 2 -induced reduction in oxygen supply should be apparent as an increase in P crit . In this study, we assessed the effects of CO 2 (46–143 Pa; 455–1410 μatm...

... and 2.2°C, respectively, but decreased when warm temperature was combined with overnight hypoxia (by 0.2 and 0.4°C, respectively). In contrast, the combination of the stressors more than doubled hypoxia tolerance in salmon and also increased hypoxia tolerance in char by 22%. Salmon had 1.2°C higher...

... diel cycles of nocturnal hypoxia (12 h normoxia:12 h hypoxia) had distinct effects on hypoxia tolerance or on several determinants of O 2 transport and O 2 utilization in estuarine killifish. Adult killifish were acclimated to normoxia, constant hypoxia, or intermittent hypoxia for 7 or 28 days...

...Shi-Jian Fu; Cheng Fu; Guan-Jie Yan; Zhen-Dong Cao; An-Jie Zhang; Xu Pang This study quantified and compared hypoxia tolerance and swim performance among cyprinid fish species from rapid-, slow- and intermediate-flow habitats (four species per habitat) in China. In addition, we explored the effects...

.... ), pp. 240 - 249 . Berlin : Springer-Verlag . Hochachka P. W. ( 1998 ). Mechanism and evolution of hypoxia-tolerance in humans . J. Exp. Biol. 201 , 1243 - 1254 . Hochachka P. W. , Stanley C. , Matheson G. O. , McKenzie D. C. , Allen P. S. , Parkhouse...

... ) and metabolism in mammals, it was of interest to see if seasonal comparisons of normothermic animals of a species capable of hibernation produce changes in their responses to hypoxia that would reflect a seasonal change in hypoxia tolerance. The species studied, the Eastern chipmunk ( Tamias striatus , Linnaeus...

... of myocardial hypoxia tolerance. In this study, we used in situ hearts from these fish as a comparative model to examine whether the cardioprotective effects afforded by hypoxic adaptation and preconditioning are additive. In situ trout hearts were exposed to severe hypoxia (perfusate P O 2 5–10 mmHg...